摘要
目的:探讨血清1,25—二羟维生素D3水平与糖尿病肾病(DN)发生发展的相关性。方法:根据479例2型糖尿病患者(T2DM)的尿微量白蛋白肌酐比值,将糖尿病患者分为糖尿病正常蛋白尿组(DM组),糖尿病肾病早期组(EDN组)和糖尿病肾病临床期组(CDN组)。检测各组血清1,25—二羟维生素D3、血糖、血脂、血清肌酐、尿素水平;以181例健康检查者为正常对照组(NC组)。结果:①T2DM各组血清1,25—二羟维生素D3水平均明显低于NC组,T2DM各组间血清1,25—二羟维生素D3水平有明显差异(P<0.05)。②血清1,25—二羟维生素D3水平与血清肌酐(Cr)、尿酸(UA)、胱抑素c(Cysc)、β2-微球蛋白(β2-MG)、甘油三酯(TG)、总胆固醇(TC)、脂蛋白a(Lpa)负相关(P<0.05)。结论:T2DM患者血清1,25—二羟维生素D3水平随着尿微量白蛋白肌酐比值的增加而降低,可能与DN的进展有关。
Objective ：To explore the correlation of serum 1, 25 dihydroxy vitamin D3 in the development of type 2 diabetes mellitus and diabetic nephropathy. Method： 479 patients with type 2 diabetes mellltus. According to urinary albumin to creatinine ratio（ACR）, the patients with type 2 diabetes mellitus were divided into normal albuminuria diabetic group （DM）, diabetic nephropathy early group （EDN group） and the diabetes nephropathy clinical period group （CDN group）. Levels of serum 1, 25 - dihydroxyl vitamin D3, glucose, lipid, creatinine, urea were measured. 81 healthy individuals were normal controls. Results： ① Serum 1, 25 - dihydroxyl vitamin D3 levels in T2DM groups were lower than that of normal controls. Serum 1, 25 - dihydroxyl vitamin 133 levels in every group of T2DM was significant difference（P〈0.05）. ② Serum 1, 25 - dihydroxyl vitamin D3 levels were negatively correlated with creatinine, urea, eystatin c, 132- MG, TG, TC, Lpa （P〈 0.05）. Conclusions： Serum 1, 25 - dihydroxyl vitamin D3 levels in T2DM groups were decreased along with the increase of 1, 25 - dihydroxyl vitamin 133 Along with the increase of ACR may be related to important of DN.
出处
《微量元素与健康研究》
CAS
2013年第5期8-10,共3页
Studies of Trace Elements and Health
基金
贵州省卫生厅科学技术基金项目GZWKJ2012-1-130
