饮食中铝含量对阿尔茨海默病风险因素的流行病学调查

The epidemiological investigation of the levels of aluminum in diet to the risk factors of Alzheimer's disease

目的:调查阿尔茨海默病(AD)患者血清中铝含量及其日常食用食品中铝的含量,探究饮食中铝含量对AD的影响。方法:采用病例对照研究,收集所有受试者血清样本并利用电感耦合等离子质谱法测试血清中铝的含量,同时调查每个受试者的相关资料,并检测其日常饮食中铝的含量。结果:病例组血清中铝的含量显著高于对照组,二者之间的差异具有统计学意义(P<0.05)。受试人群日常食用的油条铝含量严重超过国家标准,平均值达到622 mg/kg。卡方检验分析结果显示,通过食用油炸食品以及膨化食品,AD组比正常组摄入更多的铝,差别有统计学意义(P<0.05)。结论:饮食中铝的摄入可能增加AD的风险。

Objective： To investigate the levels of aluminum in serum and diet of Alzheimer＇ s disease, and to explore the affect of the diet aluminum to Alzheimer＇s disease. Methods： A case- control study was conducted, serum samples collected from patients and healthy controls were analyzed by ICP- MS to detect the levels of serum aluminum, then investigate the relevant information of each subject, and to detect the levels of aluminum in diet; Results： the levels of serum aluminum was significantly higher in AD patients than that of the control group, the difference between the two groups was statistically significant （P 〈 0.05 ）. The levels of aluminum in diet of study population was seriously higher than the national standard, the average was 622 mg/kg. The chi- square test analysis showed that AD patients intake more aluminum through the fried food and puffed food than the normal group, the difference was statistically significant （P 〈 0.05 ） ; Conclusions： The aluminum of diet may increase the risk of Arzheimer＇ s disease.