摘要
提出了气相色谱-质谱法测定感冒颗粒中山梨酸、脱氢乙酸、苯甲酸、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯等7种防腐剂含量的方法。样品经盐酸（1＋1）溶液酸化后用乙醚提取，所得提取液用DB-FFAP色谱柱分离，在选择离子监测模式下测定，以正十一烯酸为内标物。7种防腐剂的峰面积与质量浓度在1．0～40．0mg·L-1范围内呈线性关系，检出限（3S／N）在0．03～0．30mg·kg-1之间。在5．0，20．0mg·L-1两个浓度水平进行加标回收试验，7种防腐剂的回收率在82．5％～88．5％之间，相对标准偏差（72—5）在0．80％～6．79／6之间。
A method of GC-MS for the determination of seven preservatives, i.e. sorbic acid , benzoic acid , dehydroacetic acid , methyl paraben , ethyl paraben , propyl paraben and butyl paraben in granulated drugs for common cold was proposed. The drug sample was acidified with HCI （1 ＋ 1） solution and extracted with ethyl ether. The extracts were separated on DB-FFAP column, and determined under selected ion monitoring mode in MS. n-Undecylenic acid was used as internal standard. Linear relationships between values of peak area and mass concentration of the 7 preservatives were kept in the same range of 1.0--40. 0 mg L-1 , with detection limits （3S/ N） in the range of 0. 03--0. 30 mg kg-1. Tests for recovery were made at the concentration levels of 5. 0 and 20. 0 mg L- of the mixed standards, values of recovery found were in the range of 82.5--88. 5 with RSDrs （n=5） in the range of 0.80--6.7.
出处
《理化检验（化学分册）》
CAS
CSCD
北大核心
2013年第8期937-939,942,共4页
Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
