基于电子舌的穿心莲水煎液的掩味效果评价研究

Evaluation on taste-masking effect of Andrographis Herba by electronic tongue

目的探讨电子舌用于评价穿心莲掩味效果的可行性,为药物掩味研究提供参考。方法以穿心莲为苦味中药模型药,选择醋酸钠(NaAc)、甜蜜素(SC)、腺苷-5′-磷酸(AMP)、2,4-二羟基甲苯酸(DA)作为掩味剂,通过电子舌进行测定,所得数据用主成分分析法进行分析,并进行不同维度数据空间内欧氏距离计算,以苦距大小作为评价指标评价掩味效果,并与口尝结果比较。结果电子舌对SC、AMP、DA3种掩味剂的掩味效果的区分与口尝法的评价结果基本一致,但对NaAc的评价结果与口尝评价结果不一致,提示使用电子舌评价中药掩味效果需要满足一定的条件。结论电子舌在满足一定的条件下,可以用于中药掩味效果的评价。利用电子舌进行药物味觉信息评价,应运用药学、化学专业知识及相关学科的知识加以分析,逐步完善这种评价方法和模式。

Objective To evaluate the feasibility of taste-masking by electronic （E）-tongue and provide a reference for the drug taste-masking study. Methods Andrographis Herba was used as the carrier of bitter Chinese materia medica （CMM）, sodium acetate （NaAc）, sodium cyclamate （SC）, adenosine-5′-monophosphatedisodiumalt （AMP）, and 2, 4-dihydroxyhenzoic acid （DA） as the taste-masking agents. The data obtained by the E-tongue were analyzed through principal component analysis （PCA）, and Euclidean distance in the data space of different dimensions was calculated. Regarding the distance of bitterness （D） as the evaluation index, then whether the data analyzed by the E-tongue and volunteers were the same or were not investigated. Results The evaluation results of the taste-masking agents by E-tongue were similar to the taste by volunteers except NaAc, suggesting that some conditions should be required to evaluate the effect of CMM taste-masking. Conclusion This study shows that E-tongue could be used for evaluating the effect of CMM taste-masking under certain conditions. To evaluate the gustation information by E-tongue, we should use the professional knowledge of pharmacy, chemical and other related disciplines to analyze and improve this evaluation method and model gradually.