高脂血症与IgA肾病临床病理的相关性分析

The Relationship between Hyperlipidemia and Clinic Pathology of IgA Nephropathy

目的探讨高脂血症与IgA肾病临床病理的相关性。方法选取IgA肾病患者70例，根据血脂水平分为非高脂血症组（n=45）和高脂血症组（n=25），并对两组年龄、收缩压、舒张压、临床指标及病理情况进行比较。结果2组患者性别、血压等指标差异均无统计学意义（P均〉0．05）。2组患者血肌酐、尿素氮、血尿酸及24h尿蛋白定量差异均有统计学意义（P均〈0．05）。高脂血症组IgA肾病病理损害重于非高脂血症组（P〈0．05），肾小球硬化、肾小管间质病变程度和血管病变发生率较高、较重（P均〈0．05）。结论伴有高脂血症的IgA肾病患者血尿酸较高、24h尿蛋白量大，肾功能较差，病理损害较重，预后较差。

Objective To analyze the correlation between the level of serum lipid levels and the clinical and pathological features of IgA nephropathy.Methods 70 patients diagnosed as IgA nephropathy by renal biopsy in our hospital were divided into hyperlipidemia group（25 cases）and non-hyperlipidemia group（45 cases） according to the level of serum lipid.The clinical parameters and renal pathology grade were compared.Results There were significant differences between hyperlipidemia group and non-hyperlipidemia group in the incidences of the blood urea nitrogen（BUN）,creatinine（Cr）,uric acid and 24 hour urine protein amount（all P 〈 0.05）,while no differences in age,systolic pressure and diastolic pressure.Compared with non-hyperlipidaemia group,the pathological injury was severer in hyperlipidaemia group（P 〈 0.05）.The incidence of glomerular sclerosis,vascular injury, interstitial lesion and crescent was higher in hyperlipidaemia group（all P 〈 0.05）.Conclusions Compared with non-hyperlipidaemia patients, BUN,Cr, uric acid and 24 hour urine protein 1 evels were higher, the renal function,pathological injury and prognosis were worse in IgA nephropathy patients associated with hyperlipidaemia.