18F—FDGPET／CT显像评估血清LDH、HBDH、β2-MG对监测NHL结外器官累及的意义

Evaluation of the Significance of LDH,HBDH and β2-MG in Monitoring NHL Lymph Nodes External Organs Involvement by 18F-FDG PET/CT

目的用18F—FDGPETICT显像，评估血清LDH、HBDH、β2-MG对监测非霍奇金淋巴瘤（NHL）结外器官累及的意义。方法回顾分析108例临床确诊NHL患者的18F-FDGPET／CT显像及血清LDH、HBDH、β2-MG测定等临床资料。根据18F—FDGPET／CT显像结果对结外器官累及程度分级，并与血清LDH、HBDH、B2-MG水平进行比较，用ROC曲线对LDH、HBDH、β2-MG的诊断效能进行评价。结臬NHL患者结外器官累及程度越高，血清LDH、HBDH、β2-MG三项生化指标的值越高，各组内差异有统计学意义（P〈0．05）；LDH、HBDH和β2-MG诊断NHL结外器官累及的最佳临界值、灵敏度和特异度分别为215UIL、57．9％和83．3％；170U／L、55．6％和75．0％；2．15mg／L、52．3％和74．1％；诊断累及数目〉2,111～2的最佳临界值、灵敏度和特异度分别为271U／L、88．9％和87．2％；28lU/L、85．7％和98．0％；2．38mg／L、90．9％和80．0％。结论血清LDH、HBDH、B，．MG水平可作为NHL患者结外器官是否累及评估的辅助指标。

Objective To evaluate the significance of the lactate dehydrogenase（LDH）, eL-hydroxybutyrate dehydrogenase（HBDH）, [32-microglobulin（ [32-MG） in monitoring non-Hodgkin＇s lymphoma（NHL） lymph nodes external organs involvement by 18F-FDG PET/CT. Methods 108 patients with NHL underwent 18F-FDG PET/ CT.Among them,LDH,HBDH and [32-MG of 56,56 and 71 patients were measured respectively.The numbers of lymph nodes external organs involvement were divided into three groups（without involving,involving the number 1 - 2 and number 〉 2）,according to the results of PEC/CT, and then LDH,HBDH and [32-MG levels were compared.Results The lymph nodes external organs involvement were more,the levels of LDH,HBDH and [3 2-MG were higher（P 〈 0.05）.The optimal threshold value,sensitivity and specificity of LDH,HBDH and [3 2-MG in diagnosis of lymph nodes external organs involvement were 215U/L,57.9% and 83.3%, 170U/L,55.6% and 75.0%,2.15mg/L,52.3% and 74. l%,respectively.The optimal threshold value,sensitivity and specificity of LDH,HBDH and [3 2-MG in diagnosis of lymph nodes extemal organs involvement number 〉 2 and 1 - 2 were 271U/L,88.9% and 87.2%,281U/L,85.7% and 98.0%,2.38mg/L,90.9% and 80.0%,respectively.Conclusion LDH,HBDH and β 2-MG can be helpful to monitor external organ involvement in NHL.