Application of Functionalized N,S-Ketene Acetals Microwave- Assisted Three-Component Domino Reaction for Rapid Direct Access to Imidazo[1,2-a]pyridines
Application of Functionalized N,S-Ketene Acetals Microwave- Assisted Three-Component Domino Reaction for Rapid Direct Access to Imidazo[1,2-a]pyridines
摘要
Imidazo[1,2-a]pyridines have been successfully synthesized in moderate to good yields via a tandem three- component reaction of ethyl 2-（3-oxo-3-arylpropanethioamido）acetates with aromatic aldehydes and malononitrile by means of microwave irradiation using DABCO as the catalyst. The advantages of this method including high chemo- and regioselectivity make this new strategy highly attractive.
Imidazo[1,2-a]pyridines have been successfully synthesized in moderate to good yields via a tandem three- component reaction of ethyl 2-（3-oxo-3-arylpropanethioamido）acetates with aromatic aldehydes and malononitrile by means of microwave irradiation using DABCO as the catalyst. The advantages of this method including high chemo- and regioselectivity make this new strategy highly attractive.
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