摘要
An efficient methodology for highly diastereoselective synthesis ofpoly-substituted 4,5-dihydropyrrole deriva- tives from readily available common reactants in water has been developed. During domino processes, the forma- tion of pyrrole skeleton and its C2-hydroxylation and C3-arylamination were readily achieved via metal-free [3 ＋2] heterocyclization in a one-pot operation.
An efficient methodology for highly diastereoselective synthesis ofpoly-substituted 4,5-dihydropyrrole deriva- tives from readily available common reactants in water has been developed. During domino processes, the forma- tion of pyrrole skeleton and its C2-hydroxylation and C3-arylamination were readily achieved via metal-free [3 ＋2] heterocyclization in a one-pot operation.
