表皮生长因子与隐睾症关系的临床研究

Clinical study of relationship between epidermal growth factor and cryptorchidism

本文通过临床观察隐睾症儿童术前、术后血清中表皮生长因子 (EGF) ,睾酮 (T) ,5α 双氢睾酮 (5α DHT)的浓度变化和隐睾症的关系 ,以探讨EGF在隐睾发病中的作用和二者之间的关系。采用放射免疫法 (RIA)对 40例隐睾儿童术前、术后外周静脉血清EGF、T、5α DHT进行了测定 ,并与 2 4例正常儿童进行了比较。隐睾症儿童术前组血清EGF、T、5α DHT值明显低于正常儿童 ,而术后组血清EGF、T、5α DHT明显上升。隐睾症儿童血清EGF明显降低 。

The aims of the present study were to examine the relationship between the Epidermal Growth Factor(EGF) and the cryptorchidism,and significance of EGF in children with cryptorchidism as well.The levels of serum EGF,T and 5α?DHT were measured in 40 children with cryptorchidism before and after operation and in 24 normal children by Radioimmunoassay(RIA).The serum levels of EGF,T and 5α?DHT in cryptorchids before operation were lower compared with the normal children,but the serum levels of EGF,T and 5α?DHT increased significantly in 3～6 months after operation.It is likely that a low serum levels of EGF and severe damage of testicular structure are main cause of cryptorchid.