期刊文献+

喘息性支气管炎血清嗜酸性粒细胞趋化蛋白检测临床意义 被引量:4

下载PDF
导出
摘要 目的探讨喘息性支气管炎血清嗜酸性粒细胞趋化蛋白检测临床意义。方法选取201.02~2013.03符合入选标准的呼吸道合胞病毒感染喘息性支气管炎患儿78例,并选取同期进行健康体检儿童50例为健康体检组,检测嗜酸性粒细胞趋化蛋白(Eotaxin)、单核细胞趋化蛋白-1检测(MCP-1)并进行观察。结果轻度喘息组、重度喘息组、健康体检组Eotaxin、MCP-1检测值观察,健康体检组检测值明显低于轻度喘息组、重度喘息组,经统计学比较P<0.01,差异有统计学意义;喘息性支气管炎分期观察嗜Eotaxin、MCP-1检测值,并进行比较,急性期Eotaxin、MCP-1检测值显著高于恢复期、临床痊愈期经,统计学分析P<0.05差异有统计学意义。结论血清嗜酸性粒细胞趋化蛋白与气道高反应程度呈正相关,对喘息性支气管炎进行血清嗜酸性粒细胞趋化蛋白检测可以对疾病程度及临床分期进行指导。
作者 安慧萍
出处 《中国实用医药》 2013年第25期132-133,共2页 China Practical Medicine
  • 相关文献

参考文献3

二级参考文献28

  • 1董琳,黄达枢,陈小芳,方水富,吴兴利.呼吸道合胞病毒毛细支气管炎血清几种细胞因子水平变化及其意义[J].中华儿科杂志,1996,34(6):409-409. 被引量:7
  • 2Staat M A. Respiratory syncytial virus infections in children [J]. Semin Respir Infect, 2002,17( 1 ) : 15-20.
  • 3Tal A, Bavilski C, Yohai D, et al. Dexamethasone and salbutamol in the treatment of acute wheezing in infants [J]. Pediatrics, 1983, 71(1):13-18.
  • 4Sigurs N, Gustafsson P M, Bjarnason R, et al. Severe respiratory syncytial virus bronchiolilis in infancy and asthma and allergy at age 13 [J]. Am J Respir Crit Care Med, 2005,171 (2) : 137-141.
  • 5Kampen G T, Stafford S, Adaehi T, et al. Eotaxin induces degranulation and cheinotaxis of eosinophils through the activation of ERK2 and p38 mitogen-aetivated protein kinases [J]. 2000,95(6): 1911-1917.
  • 6Jibiki T, Terai M, Shima M, et al. Monocyte chemoattraetant protein 1 gene regulatory region polymorphism and serum levels of monocyte ehemoattractant protein 1 in Japanese patients with Kawasaki disease [J ]. Arthritis Rheum, 2001,44 (9) : 2211-2212.
  • 7De Lemos J A, Morrow D A, Sabatine M S, et al. Association between plasma levels of monocyte ehemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes [ J ]. Circulation, 2003,107 (5) : 690-695.
  • 8Martinovic I, Abegunewardene N, Seul M, et al. Elevated monocyte chemoattraetant protein- 1 serum levels in patients at risk for coronary artery disease [J]. Circ J, 2005,69( 12): 1484-1489.
  • 9Szalai C, Kozma G T, Nagy A, et al. Polymorphism in the gene regulatory, region of MCP-1 is associated with asthma susceptibility and severity[J]. J Allergy Clin hnmunol, 2001,108(3) :375-381.
  • 10Conti P, DiGioacchino M. MCP-1 and RANTES are mediators of acute and chronic inflammation [J]. Allergy Asthma Proc, 2001,22 (3):133-137.

共引文献23

同被引文献34

引证文献4

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部