安神补脑液与舒乐安定治疗失眠症的疗效比较

Comparison of the Curative Effects of Anshenbunao Liquid and Estazolam in the Treatment of Insomnia

目的:探讨安神补脑液治疗失眠症的临床疗效及不良反应。方法:88例失眠中老年患者进入研究,随机分为治疗组(A组,n=40)和对照组(B组,n=36),2组分别予安神补脑液与舒乐安定治疗。2组患者在治疗前和治疗第1、2、3个疗程末分别测评AIS评分,根据治疗前AIS评分确定为轻度失眠组(A1组,n=28;B1组,n=25)及重度失眠组(A2组,n=12;B2组,n=11)。以AIS总分的减分率作为疗效判定指标。记录治疗过程中出现的不良反应,每次测评同时进行常规检查。结果:A组与B组及A1组与B1组在治疗后总有效率比较均无统计学意义;A2组在第2、3个疗程后总有效率均显著低于B2组(χ2=6.13,P=0.01;χ2=4.54,P=0.03)。A、B2组及各亚组治疗后AIS评分均显著低于治疗前(均为P<0.05)。治疗第3个疗程后B2组AIS评分显著低于A2组(t=2.105,P=0.047)。A组治疗过程中不良反应少于B组。结论:安神补脑液可应用于失眠症患者的治疗,疗效与舒乐安定相当,尤其适用于失眠轻症患者,值得临床推广应用。

Objective：To investigate the clinical curative effect and adverse reactions of Anshenbunao liquid in the treatment of insomnia.Methods：Eighty eight middle and old aged patients with insomnia were included in the study and randomly divided into the treatment group（group A,n = 40） and control group（group B,n = 36）.The two groups were given Anshenbunao liquid and estazolam treatment respectively.Patients were evaluated with AIS score before treatment and at the end of the first,second and third course of treatment.According to AIS scores before treatment they were divided into mild insomnia group（group A1,n = 28;group B1,n = 25） and severe insomnia group（group A2,n = 12;group B2,n = 11）.The reducing rate of total AIS score was used for judging the therapeutic efficacy.Adverse reactions were recorded during the treatment.Routine inspections were made during each evaluation.Results：The total effective rate had no statistical significance between group A and group B or between group A1 and group B1 after treatment.The total effective rate in group A2 at the end of the second and third course of treatment were significantly lower than those of group B2（χ2 = 6.13,P = 0.01;χ2 = 4.54,P = 0.03）.The AIS scores after treatment were significantly lower than those before the treatment in group A and B and subgroups（P 0.05）.The AIS score in group B2 was lower than group A2 after the third couse of treatment（t = 2.105,P = 0.047）.The adverse reactions during the treatment in group A was less than group B.Conclusion：Anshenbunao liquid can be used in the treatment of patients with insomnia,especially for those with mild insomnia and the curative effect is similar with estazolam.It is worth of clinical application.