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实验性变态反应性脑脊髓炎与细胞凋亡 被引量：4

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摘要 实验性变态反应性脑脊髓炎 (EAE)是研究人类多发性硬化 (MS)的经典动物模型 ,EAE发病和愈复过程中细胞凋亡的情况也是目前神经生物学的研究热点。研究者们发现 ,EAE时CNS损伤区有自身反应性T淋巴细胞的凋亡 ,而且这种细胞凋亡促进了EAE的愈复和耐受状态的形成 ,这就为EAE乃至人类MS的防治提供了一条新思路。有关EAE其他细胞凋亡和影响细胞凋亡的因素也有一些研究。
作者 王惠 林嘉友 杨天祝
机构地区 中国医学科学院基础医学研究所免疫学研究室 河北医科大学基础医学研究所神经生物研究室
出处 《中国神经免疫学和神经病学杂志》 CAS 2000年第3期175-179,共5页 Chinese Journal of Neuroimmunology and Neurology
关键词 变态反应性脑脊髓炎 细胞凋亡 病理
分类号 R744.510.2 [医药卫生—神经病学与精神病学]
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参考文献18

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同被引文献43

  • 1陈慧芳,吕佩源,陈竞清,林嘉友.EAE大鼠中枢神经系统与外周免疫器官细胞凋亡的研究[J].中国神经免疫学和神经病学杂志,2004,11(5):280-282. 被引量：6
  • 2赵红如,董万利,倪建强,王涛,蒋建华.年龄因素对蛋白脂蛋白139～151诱导自身免疫性脑脊髓炎小鼠模型的影响[J].中国临床康复,2005,9(21):80-82. 被引量：1
  • 3赵红如,董万利,王涛,倪健强,陈建华.实验性自身免疫性脑脊髓炎小鼠的磁共振研究[J].中国神经精神疾病杂志,2005,31(5):351-354. 被引量：3
  • 4孟荔 欧阳建.凋亡与自身免疫病的研究进展.中外健康文摘(医药学刊),2007,4(9):31-32.
  • 5Petry KG, Boulleren AI, Pousset F, et al. Experimental allergic encephalomyelitis animal models for analyzing features of multiple sclerosis. Pathol Biol ( Paris), 2000, 48 : 48-53.
  • 6Nguyen KB, McCombe PA, Pender MP. Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. J Autoimmun, 1994, 7: 145-152.
  • 7Pender MP. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance . Immunol Cell Biol, 1999, 77 : 216-223.
  • 8Suvannavejh GC, Dal Canto MC, Matis LA, et al. Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis. J Clin Invest, 2000, 105: 223-231.
  • 9Tabi Z, Mcombe PA, Pender MP. Antigen-specific down-regulation of myelin basic protein-reactive T ceils during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T ceils in the central nervous system. Int Immunol, 1995, 7 : 967-973.
  • 10Okuda Y, Bernard CC, Fujimura H, et al. Fas has a crucial role in the progression of experimental autoimmune encephalomyelitis. Mol Immunol, 1998, 35 : 317-326.

引证文献4

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中国神经免疫学和神经病学杂志
2000年 第3期

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