重组人脑利钠肽治疗慢性心力衰竭患者早期肾功能损害的临床观察

Clinical observation on brain natriuretic peptide in the treatment of chronic heart failure patients with early renal damage

目的观察重组人脑利钠肽(recombinant human brain natriuretic peptid,rhBNP)治疗慢性心力衰竭患者早期肾损害的临床效果。方法将慢性心力衰竭患者早期肾功能损害患者41例分为两组,治疗组21例,对照组20例,治疗组在常规治疗慢性心力衰竭的基础上给予rhBNP治疗,对照组给予常规治疗。观察两组间血尿素氮(BUN)、血清肌酐(Scr)、尿微量清蛋白(MA)、肾小球滤过率(GFR)变化。结果经治疗后两组间BUN、Scr无变化,两组中MA、GFR都有好转,但治疗组改善均优于对照组(P<0.05)。结论 rhBNP在治疗慢性心力衰竭患者早期肾功能损害中,能更有效改善肾功能,保护肾功能,延缓慢性心衰病程进展。

Objective To investigate the clinical effect of ambroxol in treatment of infantile pneumonia.Methods 156 patients with infantile pneumonia were selected in our hospital from December 2010 to October 2012,who were randomly divided into 4 groups.39 patients treated conventional anti infection and symptomatic as control group.39 patients combined with ambroxol hydrochloride as observation group A.39 patients combined with ambroxol atomization as observation group B.39 patients treated atomizing inhalation of ambroxol hydrochloride and intravenous infusion of adjuvant therapy as observation group C.Symptoms improvemental situation,clinical efficacy,adverse reaction were compared.Results Body temperature returned to normal time,the disappearance time of cough,throat phlegm cries sound disappear time,pulmonary rales disappearance time,hospitalization time in observation group A and B and C were significantly lower than the control group.group C were significantly lower than group A,B and the control group.Total effective rate in group A and group B were significantly higher than the control group.group C was significantly higher than group A,group B control group.There were no significant difference in adverse reactions between every groups（P0.05）.Conclusion Effect of ambroxol in treatment for infantile pneumonia is significant,which can significantly improve clinical symptoms in children.That has high security and worthy of clinical use.