氨溴索辅助治疗小儿肺炎的临床观察

Clinical observation of ambroxol for infantile pneumonia

目的探讨氨溴索辅助治疗小儿肺炎的临床效果。方法选取本院2010年12月～2012年10月收治的小儿肺炎患者156例,随机分为4组,采用常规抗感染与对症治疗患儿39例为对照组,基础治疗联用氨溴索静脉滴注辅助治疗患儿39例为观察A组,基础治疗联用氨溴索雾化吸入辅助治疗患儿39例为观察B组,基础治疗联用氨溴索雾化吸入和静脉滴注辅助治疗患儿39例为观察C组,比较各组患儿治疗后的病症改善情况、临床疗效、不良反应情况。结果观察A组、B组C组体温恢复正常时间、咳嗽消失时间、喉内痰鸣音消失时间、肺部啰音消失时间、住院时间均明显小于对照组;观察C组总有效率均明显高于对照组、观察A组、B组,差异均有统计学意义(P<0.05)。对照组、观察A组、观察B组、观察C组间相比较,不良反应情况差异无统计学意义(P>0.05)。结论氨溴索辅助治疗小儿肺炎的疗效显著,可显著改善患儿的临床病症,安全性较高,值得临床推广使用。

Objective To investigate the clinical effect of ambroxol in treatment of infantile pneumonia. Methods 156 patients with infantile pneumonia were selected in our hospital from December 2010 to October 2012, who were randomly divided into 4 groups. 39 patients treated conventional anti infection and symptomatic as control group. 39 patients combined with ambrox- ol hydrochloride as observation group A. 39 patients combined with ambroxol atomization as observation group B. 39 patients trea- ted atomizing inhalation of ambroxol hydrochloride and intravenous infusion of adjuvant therapy as observation group C. Symptoms improvemental situation, clinical efficacy, adverse reaction were compared. Results Body temperature returned to normal time, the disappearance time of cough, throat phlegm cries sound disappear time, pulmonary rales disappearance time, hospitalization time in observation group A and B and C were significantly lower than the control group, group C were significantly lower than group A, B and the control group. Total effective rate in group A and group B were significantly higher than the control group. group C was significantly higher than group A, group B control group. There were no significant difference in adverse reactions between every groups （P 〉 0. 05）. Conclusion Effect of ambroxol in treatment for infantile pneumonia is significant, which can significantly improve clinical symptoms in children. That has high security and worthy of clinical use.