食管癌症患者血清CEA、CA125、CA19-9和β-hCG围手术期监测的意义

Esophageal cancer patients serum CEA、CA125、CA19-9 and beta-hCG perioperative monitoring significance

目的探测食管癌患者血清中CEA(癌胚抗原)、CA125(糖类抗原125)、CA19-19(糖类抗原19-9)、βHCG(β人绒毛膜促性腺激素)肿瘤标志物的水平动态变化在手术前、后对患者治疗中的价值以及意义。方法通过化学发光免疫检测法测定100例食管癌患者血清中的CEA、CA125、CA19-9、β-hCG在术前、术后的水平动态变化值,并且设立10例无心、肝、脾、肺、肾等疾病的健康患者作为对照组。结果术前实验组食管癌患者血清中的CEA、CA125、CA19-9水平明显高于健康的对照组(均P<0.01),而实验组食管癌患者血清中的βHCG水平术前和对照组差异无统计学意义(P>0.05);实验组中食管癌患者血清中的CEA、CA125和CA19-9水平术后显著低于术前(均P<0.05),而实验组食管癌患者血清中的β-hCG水平术后和术前血清水平差异无统计学意义(P>0.05);结论食管癌患者血清中CEA、CA125和CA19-9动态水平变化的监测可以作为手术疗效监测的指标,用于临床。

Objective Detection of esophageal patients serum CEA（carcinoembryonic antigen）,CA125（carbohydrate antigen 125）,CA19-19（carbohydrate antigen 19-9）,beta-hCG（beta people chorionic gonadotropin） the level of tumor markers preoperatively,the dynamic changes of patients after the treatment of value and significance.Methods By chemiluminescence immunoassays were measured in 100 cases of esophageal cancer patients in the serum CEA,CA125,CA19-9,beta-hCG in the preoperative and postoperative level dynamic change value,and set up 10 cases centerless,liver,spleen,lung,kidney diseases such as health patients as control group.Results The preoperative esophageal cancer patients in the serum CEA,CA125,CA19-9 level is obviously higher than that of the healthy control group（P0.01）,and the experimental group in the serum of patients with esophageal cancer β-hCG levels preoperative and control group was statistically significant differences（P0.05）;The experimental group in patients with esophageal cancer in the serum CEA,CA125 and CA19-9 level significantly below the preoperative（both P0.05）,and the experimental group in the serum of patients with esophageal cancer β-hCG levels postoperative and preoperative serum level of no statistical significance difference（P0.05）.Conclusion Esophageal cancer patients serum CEA,CA125 and CA19-9 dynamic level change monitoring can be used as a surgical curative effect monitoring index,used in clinical.