降钙素原、C-反应蛋白及乳酸脱氢酶联合测定对急性重型胰腺炎的早期诊断价值

Value of Procalcitonin,C-reactive protein and lactate dehydrogenase(LDH) joint determination in early diagnosis of acute severe pancreatitis

目的:探讨血清降钙素原(PCT)、C-反应蛋白(CRP)及乳酸脱氢酶(LDH)联合检测对急性重型胰腺炎(SAP)的早期诊断价值。方法:65例急性胰腺炎(AP)患者分为急性水肿型(轻型,MAP)48例和急性出血坏死型(重型,SAP)17例。分别于入院时和入院后48小时抽血检测血清降钙素原、C-反应蛋白及乳酸脱氢酶水平,判断上述指标水平变化对SAP的诊断价值。结果:入院时两组PCT、CRP及LDH水平差异无统计学意义(P>0.05);入院后48小时两组比较上述指标差异显著(P<0.05),入院时PCT、CRP和LDH对判断SAP的灵敏性分别为53%、67%和42%,入院后48小时上述指标对判断SAP的灵敏性分别为73%、100%和77%。结论:初诊为AP的患者,联合检测PCT、CRP及LDH对临床分型具有明确的指导意义,有助于临床医师及时合理施治。

Objective To explore the value of serum Procalcitonin （PCT）, c - reactive protein （CRP） and lactate dehydrogenase （LDH） united detection in early diagnosis of acute severe pancrcatitis. Method 65 patients with acute pancreatitis （AP） dcvided into a- cute ocdema （light） （MAP） with 48 cases and acute hemorrhagic necrosis type （heavy） （SAP） with 17 cases. They had blood simpling to test Procalcitonin, C - reactive protein and lactate dehydrogcnage levels in admission and 48 hours after admission ,judge the diagnosis value of the above index level change on SAP. Results The time of admission two groups on PCT, CRP and LDH level difference was statistically significant （ P 〉 0.05 ） ;48 hours after admission comparisons of the above indexes in two groups had significant difference （ P 〈 0.05 ） ,the time of admission the sensitivity of PCT,CRP andLDH to judge the SAP were 53% ,67% and 42% ,48 hours after admission the sensitivity of the SAP were 73%, 100% and 77%. Conclusion The paticnts for AP surveyed,united detection of PCT,CIRP and LDH has clear guid- ance for clinical classification with ,help clinicians timely and reasonable treatment.