前列地尔治疗对2型糖尿病肾病患者氧化应激损伤的影响

Effect of alprostadil on oxidative damage in type 2 diabetic nephropathy

目的抗氧化应激具有治疗糖尿病肾病的作用,但是前列地尔作为一种常规的抗氧化剂其作用机制尚不清楚。文中初步探讨运用前列地尔治疗对2型糖尿病肾病患者氧化应激的影响。方法 2型糖尿病肾病患者61例,分为常规治疗组(30例)和前列地尔治疗组(31例)。治疗前和治疗10d后,检测8-羟基脱氧鸟嘌呤(8-hydroxy-desoxyguanosine,8-OHdG)水平。同期检测65例健康体检者(正常对照组)血8-OHdG水平。结果治疗前,正常对照组血8-OHdG水平为(0.72±0.63)ng/ml,糖尿病肾病组血8-OHdG水平为(3.48±1.86)ng/ml,2组比较差异有统计学意义(P<0.001)。治疗10 d后,前列地尔治疗组8-OHdG水平明显下降,与常规治疗组比较有统计学意义(P<0.01)。结论前列地尔在治疗2型糖尿病肾病过程中有着显著的抗氧化应激作用。

Objective Antioxidant stress helps the treatment of diabetic nephropathy （ DN）, but the action mechanism of al- prostadil as a conventional antioxidant remains unclear. This study is to observe the effect of alprostadil on oxidative damage in type-2 DN patients. Methods Totally 61 DN patients were divided into a routine therapy group （ n = 30） and an alprostadil group （ n = 31 ）. The level of 8-hydroxy-desoxyguanosine （8-OHdG） was determined before and after 10 days of medication, and meanwhile it was also measured in another 65 healthy subjects （normal control group）. Results Before treatment, the level of 8-OHdG in the DN pa- tients was （3.48 ~ 1.86） ng/ml, significantly higher than （0.72 ~ 0.93） ng/ml in the normal control group （P 〈 0. 001＇ ）. After 10 days of medication, the 8-OHdG level showed no significant change in the routine therapy group, but markedly decreased in the alpros- tadil group, with statistically significant difference between the two groups （ P 〈 0.01 ）. Conclusion Alprostadil has a significant antioxidant stress effect in type 2 diabetic patients with nephropathy.