洛铂腔内灌注治疗恶性胸腹腔积液的临床观察

Clinical observation of lobaplatin used for intracavitary instillation on malignant pleuroperitoneal cavity hydrops

目的观察胸腹腔内灌注洛铂治疗恶性胸腹腔积液的疗效及毒副反应。方法 2010年11月至2012年11月收治32例恶性胸腹腔积液患者,经B超检查定位胸腹腔置管,尽量抽净积液,洛铂30mg/m2胸腹腔灌注,每周1次,连续2周,最多灌注4次;治疗2周后评价疗效及毒副反应。结果 32例患者均完成2次以上胸腹腔灌注,完全缓解9例(28.1%),部分缓解15例(46.9%),无变化8例(25.0%)。全组患者的总有效率为75.0%,胸腔积液有效率为80.0%,腹腔积液有效率为66.7%。毒副反应主要包括胸(腹)痛、发热、血小板减少和轻度消化道反应,经对症处理后好转。结论洛铂胸腹腔灌注治疗恶性胸腹腔积液的疗效确切,毒副反应小,值得临床推广。

Objective To observe the curative effects and adverse reaction about lobaplatin used for intracavitary instillation on malignant pleuroperitoneal cavity hydrops. Methods Thirty-two patients with malignant pleuroperitoneal cavity hydrops, locationed by B-ultrasonic wave and given puncturing and inserting catheter,were given lobaplatin for intracavitary instillation, once a week, for 2 weeks ,4 times at most. The curative effects and toxicity were evaluated after 2 weeks. Results Thirty-two patients were given intra- cavitary instillation for at least 2 times. Of all the patients, complete response （CR） was observed in 9 patients （28.1% ）, partial re- sponse in 15 patients（46. 9% ）, NS in 8 patients（25.0% ）. The response rate（RR） was 75.0%. The RR of pleural effusion and se- roperitoneum was 80.0% and 66. 7% , respectively. The toxicity mainly included chest or abdominal pain,fever,low platelets and di- gestive tract reaction. Conclusion Lobaplatin is effective used for intracavitary instillation on malignant pleuroperitoneal cavity by- drops with mild adverse reaction, so it is worth to be popularized.