不同手术方式治疗前后胃癌患者血清VEGF、MMP-3的变化及意义

Influence and significance of different operative approaches between pre - and post-treatment on the serum VEGF and MMP - 3 of patients with gastric cancer

目的:探讨采用不同手术方式治疗胃癌对患者术后血清血管内皮生长因子(VEGF)和基质金属蛋白酶-3(MMP-3)水平的影响及意义。方法:运用ELISA法检测18例健康者、31例腹腔镜胃癌根治术者及17例开腹手术者治疗前后血清VEGF和MMP-3的含量。结果:腔镜组与开腹组术前VEGF和MMP-3含量无明显差异(P>0.05),均明显高于健康者(P<0.05)。在术后1周腔镜组VEGF、MMP-3含量下降,低于开腹组,但仍高于健康者(P<0.05)。术后1月腔镜租和开腹组VEGF、MMP-3含量下降,低于术前,但仍高于健康者,腹腔镜组VEGF含量明显低于开腹组(P<0.05)。术后半年两组VEGF、MMP-3含量对比无明显差异,MMP-3降至健康者水平(P>0.05)。但VEGF含量仍高于健康者(P<0.05)。结论:腹腔镜胃癌根治术对患者机体功能影响小,VEGF、MMP-3不会过度表达,不增加肿瘤转移几率,安全可行。

Objective：To study the influence and significance of different operative approaches between pre-and post-treatment on the serum VEGF and MMP-3 of patients with gastric cancer.Methods：To detect the content of serum VEGF,MMP-3 with ELISA method in 18 cases of healthy subjects,and that of the pre-and post-treatment in 31 patients underwent laparoscopic radical gastrectomy and 17 patients underwent open surgery treatment.Results：There was no significant difference（P ＞ 0.05） between the pre-treatment contents of serum VEGF and MMP-3 of patients underwent laparoscopic radical gastrectomy or open surgery treatment,but they were both apparently higher than that of the healthy subjects （P ＜ 0.05）.A week after operation,contents of serum VEGF,MMP-3 of patients underwent laparoscopic radical gastrectomy fell and lower than those of the patients underwent open surgery treatment,but still higher than those of the healthy subjects（P ＜ 0.05）.A month after operation,contents of serum VEGF and MMP-3 of two groups patients fell lower than that of pre-treatment but still higher than that of healthy subjects.Laparoscopic group VEGF were significantly lower than the open surgery group （P ＜ 0.05）.Half a year after operation,the contents of serum MMP-3 of the two groups fell lower than those of healthy subjects （P ＜ 0.05）,but the contents of serum VEGF of the two groups still higher than that of healthy subjects（P ＜ 0.05）.Conclusion：Laparoscopic radical gastrectomy has a small influence on the body function of patients.It neither causes the overexpression of serum VEGF and MMP-3,nor increases the chances of tumor metastasis,it is safe and accessible.