NOB1在结直肠癌中的表达及其临床意义

Expression and clinical significance of colorectal cancer

目的:研究NOB1编码蛋白在结直肠癌及正常结直肠黏膜(距癌组织边缘5cm以上)、结直肠良性息肉中的表达特征。探讨结直肠癌中NOB1表达的临床病理意义。方法:利用免疫组织化学SABC法检测87例结直肠癌组织、22例正常结直肠黏膜组织18例结直肠息肉组织中NOB1的表达。结果:NOB1在结直肠癌,结直肠良性息肉及正常结直肠黏膜中的阳性表达率分别为74.7%、44.4%、13.6%,三组进行比较,差异有统计学意义(P<0.01)。细胞分化差的结直肠癌NOB1蛋白阳性率表达高(P<0.05)与患者年龄,性别,肿瘤浸润深度及淋巴结转移无明显相关性。结论:NOB1蛋白在结直肠癌中表达升高,并与大肠癌临床病理学特征有关。

Objective：Researched the expression and clinical significance of NOB1 in colorectal cancer and their corresponding normal colorectal tissue and colorectal benign polups.Methods：The expression of NOB1 was detected by SABC immunohistochemical technique in 87 cases of colorectal cancer and their corresponding normal colorectal tissue（n =22） and 18 cases of colorectal polys.Results：Positive rate of NOB1 was 74.7％ in colorectal cancer and 44.4％ in colorectal benign polyps and 13.6％ in normal colorectal tissue,with a significant difference between the two groups（P ＜ 0.01）.The expression of NOB1 was associated with differentiation grade in colorectal cancer but not with the age,gender,infiltration depth and lymphatic node metastasis in colorectal of patients.Conclusion：The expression of NOB1 is higher in colorectal cancer than in normal colorectal tissue,so NOB1 may play an important role in the progression of colorectal cancer.