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Galectin-7在外阴鳞癌中的表达及意义

Galectin - 7 expression in vulvar squamous cell carcinoma and Its clinical significance
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摘要 目的:探讨Galectin-7在外阴鳞癌中的表达与意义。方法:采用免疫组化和Western blot方法检测Galectin-7在外阴鳞癌中的表达情况。结果:Galectin-7在外阴鳞癌组织中的表达明显低于正常外阴皮肤(P=0.001)。其在临床III期的表达明显高于I、II期(P=0.035);中、低分化的表达明显高于高分化(P=0.039);有淋巴结转移的表达明显高于无淋巴结转移(P=0.020)。结论:Galectin-7的表达与外阴鳞癌的发生有关,且与外阴鳞癌的不良预后呈正相关。 Objective：To investigate the expression of Galectin-7 in vulvar squamous cell carcinoma and its significance.Methods：Immunohistochemic staining and western blot was conducted to detect the expression of Galectin-7 in vulvar squamous cell carcinoma.Results：Galectin-7 expression was significantly lower in vulvar squamous cell carcinoma tissues than in normal vulvar tissues （P =0.004）.Galectin-7 expression was significantly higher in the FIGO Ⅲ stage than in the FIGO Ⅰ and Ⅱ stages （P =0.035）.Galectin-7 expression was significantly higher in the moderately and poorly differentiated vulvar squamous cell carcinoma than in the well differentiated vulvar squamous cell carcinoma（P =0.039）.Galectin-7 expression was significantly higher in the patients with nodal metastasis than that in patients without similar condition （P =0.020）.Conclusion：Galectin-7 expression associates with occurrence of vulvar squamous cell carcinoma.And the poor prognosis of vulvar squamous cell carcinoma was positively related to expression of Galectin-7.
作者 姜英 李慧 田若阳 武昕
机构地区 中国医科大学附属第一医院妇科
出处 《现代肿瘤医学》 CAS 2013年第9期2055-2058,共4页 Journal of Modern Oncology
基金 国家自然基金(编号:30973190) 沈阳市科技计划项目(编号:F11-264-1-39)
关键词 Galectin-7 外阴鳞癌 免疫组化 免疫印迹 Galectin-7 vulvar squamous cell carcinoma immunohistochemistry western blot
分类号 R735.35 [医药卫生—肿瘤]
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参考文献15

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现代肿瘤医学
2013年 第9期

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