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微小RNA与眼底疾病 被引量：3

MicroRNA and fundus diseases
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摘要 微小RNA（miRNAs）是一类内源性的非编码小分子RNA，广泛存在于真核生物细胞中。miRNAs通过抑制mRNA翻译或降解mRNA的方式下调目的基因的表达水平，被认为是基因转录后表达调控的主要方式，参与调节细胞的增生、分化、死亡等生物学过程。近年来的研究表明，miRNAs的表达水平和／或功能的改变与糖尿病视网膜病变（DR）、年龄相关性黄斑变性（AMD）、视网膜母细胞瘤（RB）等多种严重致盲性眼底疾病的发生、发展、治疗和预后密切相关。就近年来miRNAs与眼底疾病的研究进展进行综述。 MicroRNA （miRNAs） are endogenous, small and noncoding regulatory RNAs, which widely exist in eukaryotes. MiRNAs regulate the expression of target gene by translating inhibition or mRNA destabilization. MiRNAs have been recognized as a major regulatory fashion of post-transcriptional gene expression and play important roles in many cellular biological processes, including cellular proliferation, differentiation, celt death. Alteration of expression and/or dysregulation of miRNAs are related to a wide variety of severe fundus diseases, such as diabetic retinopathy,age-related macular degeneration and retirtobiastoma. This review aimed to provide a summary of the recent progress in the effect of miRNAs on fundus diseases.
作者 肖伟(综述) 何明光(审校)
机构地区 中山大学中山眼科中心眼科学国家重点实验室
出处 《中华实验眼科杂志》 CAS CSCD 北大核心 2013年第9期897-901,共5页 Chinese Journal Of Experimental Ophthalmology
关键词 微小RNA 眼底疾病 基因表达调控 MicroRNA Fundus disease Gene expression regulation
分类号 R276.734 [医药卫生—中医五官科学]
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参考文献48

  • 1Flynt AS, Lai EC. Biological principles of microRNA-mediated regulation : shared themes amid diversity [ J ]. Nat Rev Genet, 2008, 9:831-842.
  • 2Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post- transcriptional regulation by microRNAs:are the answers in sight [ J ] ? Nat Rev Genet,2008,9 : 102-114.
  • 3Baek D,Vill6n J,Shin C,et al. The impact of microRNAs on protein output[ J]. Nature,2008,455:64-71.
  • 4Friedman RC,Farh KK, Burge CB, et at. Most mammalian mRNAs are conserved targets of microRNAs[ J]. Genome Res,2009,19:92-105.
  • 5Kloosterman WP,Plasterk RH. The diverse functions of microRNAs inanimal development and disease[ J ]. Dev Cell ,2006,11:441-450.
  • 6Ryan DG, Oliveira-Fernandes M, Lavker RM. MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity [ J ]. Mol Vis,2006,12 : 1175-1184.
  • 7Xu S, Witmer PD, Lumayag S, et al. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ- specific miRNA cluster[ J]. J Biol Chem ,2007,282 : 25053-25066.
  • 8Karali M, Peluso I, Gennarino VA, et al. miRNeye: a microRNA expression atlas of the mouse eye [ J ]. BMC Genomics, 2010,11 : 715.
  • 9Karali M, Peluso I, Marigo V, et al. Identification and characterization of microRNAs expressed in the mouse eye[ J]. Invest Ophthalmol Vis Sci, 2007,48 : 509-515.
  • 10Deo M, Yu JY, Chung KH, et al. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides [ J] . Dev Dyn ,2006,235 : 2538-2548.

同被引文献28

  • 1Flynt AS, Lai EC. Biological principles of microRNA- mediated regulation: shared themes amid diversity [J]. Nat Rev Genet, 2008, 9(11): 831-842.
  • 2Friedman RC, Farh KK, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs [J]. Genome Res, 2009, 19(1): 92-105.
  • 3Lu X C, Zheng J Y, Tang L J, et al. MiR-133b Promotes neurite outgrowth by targeting RhoA expression [J]. Cell Physiol Biochem, 2015, 35(1): 246-258.
  • 4Hart F, Huo Y, Huang C J, et al. MicroRNA-30b promotes axon outgrowth of retinal ganglion ceils by inhibiting Sema- phorin3A expression [J]. Brain Res, 2015, 1611: 65-73.
  • 5Li X, Wan X, Chen H, et al. Identification of miR-133b and RBtCC1 as independent predictors for biochemical recu- rrence and potential therapeutic targets for prostate cancer [J]. Clin Cancer Res, 2014, 20(9): 2312-2325.
  • 6Xin H, Li Y, Liu Z, et al. MiR-133b promotes neural plasti- city and functional recovery after treatment of stroke with muhipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles [J]. Stem Cells, 2013, 31(12): 2737-2746.
  • 7Fu Q, Hue J, Li S. Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition [J]. J Neuro- sci, 2007, 27(15): 4154-4164.
  • 8Mellios N, Galdzieka M, Ginns E, et al. Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia [J]. Schizophr Bull, 2012, 38 (3): 433-443.
  • 9Zylbersztejn K, Petkovic M, Burgo A, et al. The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion [J]. J Cell Biol, 2012, 196(1): 37-46.
  • 10Syed Y A, Hand E, Mobius W, et al. Inhibition of CNS rem- yelination by the presence of semaphorin 3A [J]. J Neurosei, 2011, 31(10): 3719-3728.

引证文献3

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中华实验眼科杂志
2013年 第9期

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