67例未分化结缔组织病患者尿隐血和尿红细胞位相临床追踪观察

The Clinical Follow-up Observation on Urine Occult Blood and Morphology of Red Blood Cells of 67 Patients with Undifferentiated Connective Tissue Diseases

目的:追踪观察未分化结缔组织病(undifferentiated connective tissue disease,UCTD)患者尿隐血和尿红细胞位相的动态变化。方法:选取67例UCTD患者,每3个月进行中段尿尿液分析和尿红细胞位相检查,追踪1年,观察各指标变化情况。结果:一年后,67例UCTD患者尿隐血阳性由纳入观察时的48例(71.64%)上升到55例(82.09%),尿红细胞位相异常(畸形红细胞>80%)者由55例(82.09%)上升到60例(89.55%)。尿蛋白阳性者由11例(16.42%)上升到17例(25.37%)。67例患者5次检查尿隐血阳性率及尿红细胞位相异常阳性率均高于尿蛋白阳性率,差异有统计学意义(χ2分别为9.52,12.36,P值均<0.05)。结论:UCTD患者有尿隐血和尿红细胞位相异常,轻微但缓慢加重,可能与潜在肾损害有关。

Objective：To observe the dynamic changes of occult blood and morphology of red cells in urine of patients with Undifferentiated Connective Tissue Diseases. Methods ：67 Patients with UCTD were enrolled. Urine occult blood and morphology of red cells were examined every three months in a span of one year. Results：48 cases （71.64%） of UCTD were urine occult blood positive, 55 cases （82.09%） of UCTD had abnormal morphology of red cells as the number of deformed RBC in urine was more than 80%. 11 case （ 16.42% ） of UCTD were urinary protein positive. After one year, 55 cases （82. 09% ） were urine occult blood positive, 60 eases（89. 55% ） had abnormal morphology of red cells, and 17 case （25.37%） of UCTD were urinary protein positive. Both the rate of positive urine occult blood and abnormal morphology of red cells were higher than the rate of positive urinary protein, and the difference has statistically significance. Conclusion：Patients with UCTD have a slight but slow exacerbating occult blood and abnormal morphology of red cells in urine, It may be related to the potential kidney damage.