3492例生殖器炎症患者假丝酵母菌病原学及药敏情况分析

Analysis of Etiological and Drug Sensitiveness of Candida albican of 3492 Patients with Genital Inflammation

目的:了解江门地区生殖器假丝酵母菌病病原菌分布及药敏情况。方法:采用科玛嘉假丝酵母菌显色培养基和YBC(酵母菌)鉴定卡对3 492例生殖器炎症患者标本的致病真菌进行分离和鉴定,用ROSCO纸片扩散法检测分离菌株对制霉菌素、酮康唑、氟康唑、伊曲康唑、咪康唑和特比奈芬的药敏情况。结果:共分离出11种891株致病假丝酵母菌,其中白色假丝酵母菌占85.19%,热带假丝酵母菌占7.41%,近光滑假丝酵母菌占3.37%,其他假丝酵母菌占4.03%。891株假丝酵母菌对制霉菌素、酮康唑、氟康唑、伊曲康唑、咪康唑和特比奈芬的敏感性分别为98.09%、95.96%、88.33%、71.42%、45.68%和35.81%。结论:江门地区生殖器假丝酵母菌病致病菌种类较多,对药物的敏感性有降低趋势,耐药菌株在假丝酵母菌的构成比中有增高趋势,应加强假丝酵母菌的检测和药敏分析。

Objective：To investigate the distribution of pathogenic bacteria in patients with genital candidiasis and drug resistance in Jiangmen area. Methods：The pathogenic fungi in 3492 cases of genital specimens were separated and identified by using CHROMagar Candida color cul- ture medium and YBC （yeast） identification card. ROSCO disk diffusion method was used to e- valuate the susceptibilities of the pathogenic fungi to nystatin, ketoconazole, fluconazole, micon- azole, Ima Yasu and Binet finn separately. Results：A total of 11 species and 891 strains of isola- ted Candida were separated, the Candida albicans accounted for 85.19%, Candida tropicalis ac- counted for 7.41%, nearly smooth Candida accounted for 3.37%, other Candida accounted for 4. 03%. The sensitivity of 891 strains of Candida to nystatin, ketoconazole, fluconazole, micon- azole, Ima Yasu and Binet Finn were 98.09%, 95.96%, 88.33%, 71.42%, 45.68% and 35.81% respectively. Conclusion：The pathogenic species of genital candidiasis in Jiangmen area increased, and the sensitivity to the drug decreased. There was a trend of higher ration of resistant strains in Candida albicans. We should strengthen the detection and analysis of drug sensitivity of Candida albicans.