速度向量成像技术评价颈总动脉管壁弹性与冠心病及其病变程度的相关性

Correlation between carotid elasticity measured by velocity vector imaging and the severity of coronary artery stenosis in pa tients with coronary artery disease

目的应用速度向量成像(velocity vector imaging,VVI)技术评价冠心病(coronary artery disease,CAD)患者颈总动脉管壁弹性及其与冠状动脉病变程度的相关性,探索无创评估冠状动脉病变程度的方法。方法根据冠状动脉造影结果选取冠心病患者60例,分别为单支病变组19例,双支病变组19例,多支病变组22例,另外选取冠状动脉造影、心电图及常规超声心动图检查结果正常者20例作为对照组。应用VVI技术定量分析各组颈总动脉短轴各壁平均收缩期峰值速度(Vs)、峰值应变(Ss)及峰值应变率(SRs),计算冠脉阻塞积分(coronary artery obstacle score,CAOS)并进行对比分析。结果颈总动脉短轴各壁平均Vs、Ss及SRs测值:多支病变组与双支病变组均低于正常对照组(P<0.05),多支病变组低于单支病变组(P<0.05),单支病变组与正常对照组对比无统计学意义。颈总动脉短轴各壁平均Vs与CAOS积分呈负相关(P<0.05)。结论 VVI技术检测冠心病患者颈总动脉短轴各壁平均Vs、Ss及SRs随冠状动脉病变程度加重明显降低,有望成为早期无创预测冠心病病变程度的新指标。

[Abstract] Objective To investigate the correlation between carotid elasticity measured by velocity vector imaging （VVI） and the severity of coronary artery stenosis in patients with coronary artery disease （CAD）. Methods Totally, 80 cases suspected with CAD were examined by eardioangiography. All the cases were divided into non-CAD group（control group） and three CAD groups according to the severity of coronary artery stenosis on CAG. We measured Carotid elastic- ity parameters including radial systolic average velocity （Vs）, strain （Ss） and strain rate （SRs） by VVI technique, calcu- lated coronary artery obstacle score （CAOS） on CAG, and then compared them. Results The arotid radial Vs, Ss and SRs in the multi-vessel disease group and double-vessel disease group were significantly lower than those in the control group （ P 〈0.05）, the values of multi-vessel disease group were significantly lower than those in the single-vessel disease group （ P 〈0.05）. There was no significant difference between the single-vessel disease group and the control group （ P 〈0.05）. The arotid radial Vs was negatively correlated with CAOS （ P 〈0.05）. Conclusion The arotid radial Vs, Ss and SRs measured by VVI decreased with the severity of CAD could be used to predict the severity of CAD non-invasively.