直角边缘囊袋张力环预防兔后囊膜混浊的实验研究

Preventive effect of sharp-edged capsule tension ring on posterior capsule opacification

目的:探讨直角边缘囊袋张力环(capsule tension ring,CTR)预防兔后囊膜混浊(posterior capsule opacification,PCO)的作用。方法:新西兰兔20只随机分为两组,进行超声乳化晶状体摘除术后,实验组植入CTR和CraneOV-55C人工晶状体(intraocular lens,IOL),对照组只植入CraneOV-55CIOL。观察术后并发症和PCO情况。术后3mo行光镜和透射电镜检查,观察晶状体后囊膜的形态学变化。结果:术后3mo实验组和对照组都发生了明显的PCO(P>0.05),各组Soemmering环形成程度无统计学差异(P>0.05)。病理学检查发现,两组兔赤道部晶状体上皮细胞增生形成了巨大的Soemmering环,大量晶状体上皮细胞移行至后囊膜。结论:直角边缘CTR未能预防兔PCO的发生,有必要对其进一步改进。

AIM： To evaluate the effect of sharp-edged capsule tension ring（CTR） on posterior capsule opacification（PCO）. METHODS： Twenty eyes of New Zealand white rabbits were randomly divided into two groups. After phacoemulsification, the experimental group was implanted with CTR and Crane OV-55C intraocular lens （IOL）, and the control group was implanted with Crane OV-55C IOL only. Complications and PCO were observed by slit lamp microscope. Three months after surgery, light microscope and transmission electron microscope examinations were performed. RESULTS： There was no statistically significant difference between the experimental group and the control group about PCO and Soemmering＇s ring formation （P0.05）. Pathological evaluations revealed lens epithelial cells （LECs） accumulated at the equatorial capsule forming a large Soemmering＇s ring and abundant LECs were migrated onto the posterior capsule forming a thick layer in both experimental group and the control group. CONCLUSION： Sharp-edged CTR fail to retard PCO formation and development in rabbits and it is nessessary to improve it.