不同程度远视屈光不正性弱视儿童的图形视觉诱发电位

Pattern visual evoked potential in varying degrees hyperopic refractive amblyopic children

目的:了解不同程度远视屈光不正性弱视儿童的图形视觉诱发电位(Pattern visual evoked potential,P-VEP)特征。方法:2011-05/2012-08在我院就诊的远视屈光不正性弱视儿童,按不同最佳矫正视力(best corrected vision acuity,BCVA)分为3组,P-VEP检查分析比较不同组间及与正常儿童的P100波峰潜时和振幅的变化。结果:正常组P100波峰潜时101.43±6.82ms,P100波振幅为11.27±5.38μV。在不同程度弱视组间P100波峰较正常组潜时延迟,分别为视力高于0.5组110.54±8.47ms,视力0.3～0.5组118.76±6.21ms,视力低于0.3组124.54±7.36ms,且各组间差异有统计学意义(P<0.05)。P100波振幅均较正常下降,分别为轻度组9.94±5.28μV,中度组8.57±7.21μV,重度组7.49±5.07μV,各组间比较差异有统计学意义(P<0.05)。结论:远视屈光不正弱视儿童的图形视觉诱发电位弱视眼的P100波峰潜时延迟、P100波振幅下降。且P100波峰潜时延迟、P100波振幅下降与弱视程度相关。

AIM： To observe pattern visual evoked potential （P-VEP） of varying degrees hyperopic refractive amblyopic children. METHODS： We did P-VEP examination for the hyperopic refractive children from May 2011 to August 2012. We divided these children into three groups according to different best corrected vision （BCV）： better than 0.5 amblyopic group, 0.3-0.5 amblyopic group and lower than 0.3 amblyopic group. Their P100 latency and amplitude were measured and compared with normal children group. RESULTS： The healthy eye＇s P100 latency was 101.43±6.82ms, P100 amplitude was 11.27±5.38μV. P100 latency delay and P100 amplitude decline in amblyopic group. Better than 0.5 amblyopic group, 110.54±8.47ms, 9.94±5.28μV; 0.3-0.5 amblyopic group 118.76±6.21ms, 8.57±7.21μV; and lower than 0.3 amblyopic group 124.54±7.36ms, 7.49±5.07μV. P100 latency and amplitude have significant different between groups （P0.05）. CONCLUSION： P100 latency delay and P100 amplitude decline in hyperopic refractive amblyopia and the changes are associated with degree of amblyopia.