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神经肽Y及其受体与癫痫间 被引量：1

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摘要 神经肽Y（neuropeptide Y,NPY）即神经肽酪氨酸,是由36个氨基酸构成的一种活性多肽,属于胰多肽家族,广泛分布于中枢和外周神经系统中,是哺乳动物神经系统内含量最丰富的多肽之一,与焦虑、癫痫间以及某些神经退行性疾病的发生发展存在密切联系[1]。近年来大量研究表明,癫痫间发病的主要因素是中枢神经系统兴奋性与抑制性机制失衡从而导致神经元兴奋性异常增高,
作者 徐晓雪 徐承伟 张朝东
机构地区 中国医科大学附属第一医院神经内科 中国医科大学神经病学研究所
出处 《卒中与神经疾病》 2013年第4期248-250,共3页 Stroke and Nervous Diseases
关键词 神经肽Y 癫痫 中枢神经系统兴奋性 外周神经系统 神经退行性疾病 受体 神经肽酪氨酸 神经元兴奋性
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献25

  • 1Decressac M, Barker RA. Neuropeptide Y and its role in CNS disease and repair. Exp Neurol, 2012 238(2) : 265-272.
  • 2Decressac M, Barker RA. Neuropeptide Y and its role in CNS disease and repair. Exp Neurol, 2012 238(2) :265-272.
  • 3Ana PS, Joana L, Sara X, et al Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and con- tributes to excitability of the hippocampus in status epileptics. FASEB J, 2007 21 (3) : 671-681.
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  • 5Walther C, Morl K, Beck-Sickinger AG. Neuropeptide Y recep- tors: ligand binding and trafficking suggest novel approaches in drug development. J Pept Sci, 2011, 17(4): 233-246.
  • 6Cardoso A, Freitas-da-Costa P, Carvalho LS, et al Seizure-in- duced changes in neuropeptide Y-containing cortical neurons, Po- tential role for seizure threshold and epileptogenesis. Epilepsy Behav, 2010, 19(4): 559-567.
  • 7Drexel M, Kirchmair E, Wieselthaler-Ho1zl A, et al Somatosta- tin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-inducedepilepsy. J Neuro- pathol Exp Neurol, 2012, 71(4):312-329.
  • 8Cardoso A, Freitas-da-Costa P, Carvalho IS, et al. Seizure-in- ducedchanges in neuropeptide Y-containing cortical neurons: Po- tential role for Seizure threshold andepileptogenesis Epilepsy Be- hay,2010, 19(4) :559-567.
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同被引文献14

  • 1Lundberg JM, Tatemoto K. Pancreatic polypeptide family (APP, BPP, NPY and PYY ) in relation to sympathetic vasoconstriction resistant to alpha-adrenoceptar blockade [J]. Acta Physiol Scand, 1982,116(4) :393-402.
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  • 3Cardoso A, Freitas-da-Costa P, Carvalho LS, et al. Seizure-induced changes in neuropeptide Y-containing cortical neurons: potential role for seizure threshold and epileptogenesis [J]. Epilepsy Behav, 2010, 19(4) :559-567.
  • 4Mao X, Ma P, Cao D, et al. Altered expression of GABAA receptors (a4, c2 subunit), potassium chloride cotransporter2 and astrogliosis in tremor rat hippocampus [J]. Brain Res Bull, 2011,86 (5-6) : 373-379.
  • 5Xu X, Guo F, Lv X, et al. Abnormal changes in voltage-gated sodium channels Navl.1, Navl.2, Navl.3, Navl.6 and in calmodulin/ calmodulin-dependent protein kinase II ,within the brains of sponta- neously epileptic rats and tremor rats [ J ]. Brain Res Bull, 2013,96 : 1-9.
  • 6Drexel M, Kirchmair E, Wieselthaler-Holzl A, et al. Somatostatin and neuropeptide Y neurons undergo different plasticity in parahip- poeampal regions in kainic acid-induced epilepsy [J]. J Neuro- pathol Exp Neurol,2012,71(4) :312-329.
  • 7Silva AP, Xapelli S, Pinheiro PS, et al. Up-regulation of neuropep- tide Y levels and modulation of glutamate release through neuropep- tide Y receptors in the hippocampus of kainate- induced epileptic rats[J]. J Neurochem,2005,93( 1 ) : 163-170.
  • 8Mao X, Cao Y, Min D, et al. RP-LC with fluorescenee deteetion of amino acids in rat brain synaptosomes [J]. Chromatographia, 2011, 73(1-2) : 157-163.
  • 9Corvino V, Marehese E, Giannetti S, et al. The neuroprotective and neurogenie effects of neuropeptide Y administration in an animal model of hippocampal neurodegeneration and temporal lobe epilep- sy induced by trimethyltin [J]. J Neuroehem, 2012, 122 (2) : 415 -426.
  • 10Gotzsche CR, Nikitidou L, Sorensen AT, et al. Combined gene over- expression of neuropeptide Y and its receptor Y5 in the hippocam- pus suppresses seizures [ J ]. Neurobiol Dis, 2012,45 ( 1 ) : 288-296.

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卒中与神经疾病
2013年 第4期

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