皮肤狼疮带试验在酒渣鼻皮损中的检测意义

The Significance of the Lupus Band Test of Rosacea

目的探讨皮肤狼疮带试验(LBT)在酒渣鼻中的检测意义,并与系统性红斑狼疮进行比较。方法用直接免疫荧光技术检测酒渣鼻患者皮损,以及系统性红斑狼疮患者外观正常皮肤或皮损中真表皮交界处免疫球蛋白或补体的沉积,并同时与其主要临床症状进行统计分析。结果酒渣鼻73例,LBT阳性有14例,阳性率19.18%(14/73)。免疫球蛋白阳性率分别是IgA(15.07%)、C3(12.33%)、IgG(10.95%)、IgM(9.59%)和纤维蛋白原(0%)。系统性红斑狼疱150例,LBT阳性128例,阳性率85.33%(128/150)。其中,IgM阳性率最高(72.67%)、依次是IgG(68.00%)、IgA(61.33%)、补体C3(55.33%)和纤维蛋白原(28.67%)。结论皮肤狼疮带试验在酒渣鼻中具有一定的阳性率,其用于临床诊断时应注意结合临床表现及实验室相关检查综合评估。

Objective To explored the clinical significance of the lupus band test in rosacea, and compared with system lupus erythematosus. Methods By using the direct immunofluoresence, we detected the presence of immunoglobulin and complenent C3, which was deposited on the basement membrane zone of rosacea and lesions or normal skin of system lupus erythematosus, and made statistical analysis with the result and major signs of rosacea and system lupus erythematosus. Results The total positive rate of lupus band test in 73 rosacea cases was 19.18%（14/73）.The deposit pattern was IgA 15.07%, C3 12.33%, IgG 10.95%,IGM 9.59% and fibrinogen （0%） respectively. The total positive rate of lupus band test in 150 system lupus erythematosus cases was 85.33%（128/150）. The deposit pattern was IgM 72.67%, IgG 68.00%, lgA 61.33%, C3 55.33%, and fibrinogen 28.67% respectively. Conclusion The lupus band test had a certain positive rate in rosacea. Therefore, when lupus band test used for clinical diagnosis, we should pay attention to the comprehensive assessment with the clinical manifestations and laboratory examination.