复方嗜酸乳杆菌治疗对早期肝硬化患者补体和T淋巴细胞亚群的影响

Effect of treatment with compound Lactobacillus acidophilus on complements and T lymphocyte subsets in patients with compensated liver cirrhosis

目的:探讨口服复方嗜酸乳杆菌治疗早期肝硬化患者对血清补体和外周血T淋巴细胞亚群的影响.方法:选择66例早期肝硬化患者,根据就诊顺序随机分为对照组和治疗组,对照组予以常规保肝对症治疗,治疗组在对照组治疗的基础上加服复方嗜酸乳杆菌,1.0 g/次,3次/d,疗程为12 wk.观察两组患者治疗前后血清补体和外周血T淋巴细胞亚群的变化.结果:治疗组患者治疗后补体C3、C4水平(0.97 g/L±0.16 g/L、0.22 g/L±0.05 g/L)较治疗前(0.85 g/L±0.24 g/L、0.15 g/L±0.07 g/L)明显增高(P<0.05);患者外周血T淋巴细胞亚群CD4+(37.9%±6.5%)、CD4+/CD8+(1.6%±0.5%)较治疗前C D4+(33.8%±8.6%)、C D4+CD8+(1.3%±0.7%)明显增加(P<0.05).结论:口服复方嗜酸乳杆菌补充菌群能调节肠道菌群失调,具有一定的免疫调节作用.

AIM： To explore the effect of early oral com- pound LactobacilIus acidophilus on complements and T lymphocyte subsets in patients with com- pensated liver cirrhosis. METHODS： Sixty-six patients with compensated liver cirrhosis were randomly divided into ei- ther a control group or a treatment group. The control group received conventional symptom- atic treatment, while the treatment group was treated with compound Lactobacillus acidophilus （1.0 g, three times per day） for 12 wk on the ba- sis of conventional symptomatic treatment. The changes in serum complements and T lympho- cyte subsets between before and after treatment were observed and compared between the two groups of patients.RESULTS： After treatment, the levels of com- plements C3 and C4 （0.97 g/L ± 0.16 g/L vs 0.85 g/L ± 0.24 g/L, 0.22 g/L ± 0.05 g/L vs 0.15 g/L ± 0.07 g/L, both P 〈 0.05） and the percentages of CD4± and CD4±/CD8± T lymphocyte subsets （37.9% ± 6.5% vs 33.8% ± 8.6%, 1.6% ± 0.5% vs 1.3% ± 0.7%, both P 〈 0.05） were significantly in- creased in the treatment group. CONCLUSION： Oral compound Lactobacillus aci- dophilus can regulate intestinal flora imbalance and modulate immunity in patients with com- pensated liver cirrhosis.