六盘水市行胃镜检查幽门螺旋杆菌感染的调查及防治策略

Prevalence of and risk factors for Helicobacter pylori infection in patients who underwent gastroscopy from 2010 to 2012 in Liupanshui city

目的:统计2010-2012年六盘水市行胃镜患者幽门螺旋杆菌(Helicobacter pylori,H.pylori)感染状况,并讨论其防治策略.方法:回顾性分析六盘水市2010-2012年行胃镜检查的患者59524例,通过H.pylori染色病理学诊断,统计分析不同年龄段、不同胃部疾患中H.pylori感染状况,H.pylori感染相关因素多元Logistic回归分析以及三联疗法治疗H.pylori效果分析.结果:在各年龄段中H.pylori的阳性率不同,呈现H.pylori阳性率随年龄上升而增高的趋势,而不同胃部疾患H.pylori阳性率亦不同,其中阳性率较高的有溃疡病、胃癌与慢性萎缩性胃炎,各组两两比较(除慢性萎缩性胃炎与胃癌外),差异均具有统计学意义(2=12.41,P<0.05).H.pylori感染的相关因素为年龄(=0.679,S.E.=0.334,Wald=14.203,OR=1.989,P<0.05)、性别(=0.564,S.E.=0.432,Wald=16.353,OR=1.868,P<0.05)、饮食习惯(=0.546,S.E.=0.449,Wald=17.293,OR=1.787,P<0.05)、饮水习惯(=0.673,S.E.=0.308,Wald=15.203,OR=1.592,P<0.05)、家庭人员数(=0.599,S.E.=0.364,Wald=18.727,OR=1.329,P<0.05)、居住条件(=0.653,S.E.=0.362,Wald=15.363,OR=1.363,P<0.05)、养家畜(=0.692,S.E.=0.388,Wald=15.305,OR=1.565,P<0.05)等5个因素.结论:六盘水市行胃镜患者H.pylori感染率较高,与溃疡病胃癌等发病关系密切,须重视H.pylori的预防工作.

AIM： To investigate the prevalence of and risk factors for Helicobacter pylori （H. pylori） infection in patients who underwent gastroscopy from 2010 to 2012 in Liupanshui city and to discuss its preventive strategies. METHODS： A total of 59524 patients who un- derwent endoscopy from 2010 to 2012 in Liu-panshui were retrospectively analyzed to inves- tigate the prevalence of and risk factors for H. pylori infection. RESULTS： The positive rate of H. pylori in- creased gradually with age. The positive rates of H. pylori in different gastric lesions were dif- ferent. Ulcer disease, gastric cancer and chronic atrophic gastritis had significantly higher posi- tive rates （χ2 = 12.41, P 〈 0.05）. The risk factors for H. pylori infection included age （β = 0.679, S.E.= 0.334, Wald = 14.203, OR = 1.989, P 〈 0.05）, gender （β= 0.564, S.E. = 0.432, Wald = 16.353, OR = 1.868, P 〈 0.05）, diet （β = 0.546, S.E. = 0.449, Wald = 17.293, OR = 1.787, P 〈 0.05）, drinking habit （13 = 0.673, S.E.= 0.308, Wald = 15.203, OR = 1.592, P 〈 0.05）, family size （β= 0.599, S.E. = 0.364, Wald = 18.727, OR = 1.329, P 〈 0.05）, living con- ditions （β = 0.653, S.E.= 0.362, Wald =15.363, OR = 1.363, P 〈 0.05）, and rearing animals （β = 0.692, S.E. = 0.388, Wald = 15.305, OR = 1.565, P 〈 0.05）. CONCLUSION： The positive rate of H. pylori in- fection in patients who underwent gastroscopy in Liupanshui is high, suggesting that H. pylori infection is closely related with the occurrence of gastric ulcer and gastric cancer.