急性冠状动脉综合征患者血浆髓过氧化物酶水平与病变程度的相关性

An Analysis on Correlation of Plasma MyeloperoxidaseLevels with Severity of Coronary Lesions in Patients with Acute Coronary Syndrome

目的:探讨血浆髓过氧化物酶(MPO)水平与急性冠状动脉综合征(ACS)冠状动脉病变程度的相关性。方法:81例冠心病患者分为ACS组(54例)及稳定型心绞痛组(SAP组,27例),其中ACS组54例,SAP组27例,30例冠状动脉造影结果正常者为对照组,采用酶联免疫吸附法(ELISA)测定血浆MPO水平,冠状动脉造影判定病变血管支数及血管狭窄程度,分析MPO水平与病变程度的相关性。结果:MPO在ACS组中的浓度明显高于SAP组和对照组,差异具有统计学意义(P<0.05),而在SAP组与对照组之间的差异无统计学意义(P>0.05);MPO在单支、双支及三支病变组中明显高于对照组,差异具有统计学意义(P<0.05);在单支、双支及三支病变组之间差异无统计学意义(P>0.05);血浆MPO浓度与冠脉病变支数无相关性(r=0.18,P>0.05),与冠脉狭窄程度呈正相关(r=0.52,P<0.05)。结论:血浆MPO水平与斑块的不稳定性有关,与冠状动脉病变的狭窄程度显著相关。

Objective： To evaluate the association between plasma myeloperoxidase （MPO） level and severity of coronary lesions in acute coronary syndrome （ACS） patients. Methods： Eighty-one patients with coronary heart disease （CHD） were divided into acute myocardial infarction （AMI） group （n = 26） , unstable angina pectoris （UAP） group （ n = 28 ） and stable angina pectoris （SAP） group （ n = 27）, and 30 normal subjects without CHD that confirmed by coronary angiography were served as con- trol group. The plasma level of MPO was measured by enzyme linked immunesorbent assay （ELISA）. Results： The plasma levels of MPO were obviously higher in groups AMI and UAP than those in SAP and control groups （ P 〈 0. 05 ） , and the mean level of plasma MPO in SAP group was not different sig- nificantly from that in control group （ P 〉 0.05 ）. The plasma levels of MPO in patients with single, double, or three vessel lesion were obviously higher than that in control group （ P 〈 0. 05 ）, but they were not significantly different among single, double, and three vessel lesion groups （P 〉 0. 05 ）. Conclusions ： Plasma level of MPO is associated with instability of coronary plaques, and is significant- ly associated with severity of coronary stenosis.