炎症性肠病生物标志物的应用

Application of biomarkers in inflammatory bowel disease

近年来，随着人们饮食结构及环境等因素的改变，炎症性肠病的发病率不断上升，逐年引起人们的重视。对于炎症性肠病的诊断、疾病活动性评估、治疗效果监测、疾病复发的预测等方面尚缺乏简便、无创且相对特异的方法，其中以内镜及组织病理活组织检查最为准确，但因其有创、耗时，患者常难以接受。近年来，随着对炎症性肠病机制研究的不断深入，一些无创、简便、特异性较高的生物标志物不断出现，尤其是某些粪便生物标志物，为炎症性肠病的诊疗提供了较大的帮助。

Recently, with the factors such as diet and environmental has changed a lot, the incidence of inflammatory bowel disease （IBD） increased year by year, which has attract the attention of the public gradually. There is no simple, noninvasive and relatively specific indicators which could assist the diagnosis, diseases activity evaluation, treatment effect monitoring, and prediction of disease recurrence possibility of IBD, endoscopic examination and histo-pathologic biopsy is the most accurate method used in clinical , but it has the disadvantages of invasive and time consuming which is poorly accepted by patients with IBD. In recent years, with the further research of IBD, a series of noninvasive, convenience and high specificity biomarkers of IBD have been undergone evaluation, especially some fecal biomarkers.