鹰视飞秒FS200与Moria M2110微型角膜板层刀制作的角膜瓣厚度及形态观察

Obversation of cornea flaps' characters created by Wavelight FS200 and Moria M2 110

目的探讨应用飞秒激光鹰视FS 200制作的角膜瓣的形态及其厚度的相关影响因素,并与传统微型角膜刀Moria 110角膜板层刀进行对比。方法 LASIK术后1个月应用傅立叶前节OCT(OPTOVUE RTVue-100)测量中央角膜瓣厚度,角膜上0度、90度两条经线所在截面上特定10个点的角膜瓣厚度,并与Moria 110刀的结果进行对比。结果 FS200飞秒激光制瓣组平均角膜瓣厚度为112.2±3.2μm;变异范围18.3±4.1μm;Moria微型角膜刀110制瓣组平均角膜瓣厚度为151.1±14.9μm;变异范围42.6±14.5μm;两组间有显著性差异(P<0.01)。飞秒激光制作的角膜瓣形态规整、均一,形状近似规则的平面,中央厚度与周边厚度没有统计学差异(P>0.05)。微型角膜刀制作的角膜瓣中间薄,周边厚,形状近似一弯月形的透镜;中央、旁中央、周边区角膜瓣厚度存在明显的差异(P<0.05)。结论应用Wavelight FS200飞秒激光制作的角膜瓣形态均一规整,精确度高,可控性强,稳定性好且操作更安全,是薄瓣LASIK的首选。

Objective To compare the features of corneal flaps created using the FS200 and Moria M2 microkeratome 110 μm-knife. Methods A pilot and prospective study was designed. Ninety eyes of forty five patients were enrolled in this clinical trial. The patients were divided into the FS200 group （50 eyes） and the M2 microkeratome 110 μm-knife group （40 eyes） with matching demography. Fourier-domain optical coherence tomography （RTVue OCT） was used to measure flap thickness by 10 settings on 90 corneas at one month post-operatively. The features of the laser in situ kera- tomileusis （LASIK） flaps were analyzed on the basis of the outcomes. Written informed consent was obtained from each patient prior to LASIK. Results The mean flap thickness of the FS200 group was considerably thinner than that of the Moria 110 group （ 112.2 ± 3.2 μm versus 151.1 ± 14.9 μm）, and the same result could be found in the variable range of the two groups （ 18.3 ±4.1 of the FS200 versus 42.6 ~ 14.5 of the M110） simultaneously. The corneal flaps in the FS200 groups showed a flat shape and in the Moria 110 group showed a meniscus shape. The central flap thick- ness of the FS200 group was not evidently different from that of peripheral（ P 〉 0.05 ）, but in the Moria 110 group, the central flap thickness was obviously thinner than the peripheral thickness （ P 〈 0.05 ）. Conclusion The shape of flaps created using the FS200 is more uniform and closer to the expected thickness of 110 μm than the ones created using the Moria M2 110 microkeratome.