摘要
Toll样受体是固有免疫系统中重要的模式识别受体,介导病原体及内源性损伤相关分子诱发的各种免疫防御反应。近年来,研究发现Toll样受体2在各种心血管疾病,包括动脉粥样硬化、冠心病、心肌缺血再灌注损伤等的病理生理过程中发挥着重要作用。本文拟对Toll样受体2在心血管疾病中的研究进展做一综述。
Toll-like receptors are the important pattern recognition receptors of innate immune system,which mediate the immunological defence response against pathogen or endogenous damage associated molecules.Recently,more and more researches indicated that Toll-like receptor 2 played vital roles in the pathophysiology of many cardiovascular diseases,including atherosclerosis,coronary diseases,cardiac ischemia-reperfusion injury.In the current report,we review the research progress on the role of Tolllike Receptor 2 in cardiovascular diseases.
出处
《生理科学进展》
CAS
CSCD
北大核心
2013年第4期259-263,共5页
Progress in Physiological Sciences
关键词
TOLL样受体2
固有免疫
炎症反应
心血管疾病
Toll-like receptor 2
innate immunity
inflammatory response
cardiovascular diseases
