摘要
血管平滑肌细胞(VSMC)从中膜向内膜的迁移是动脉粥样硬化斑块形成、血管狭窄以及血管介入术后再狭窄的关键步骤。Rho相关激酶(Rho-associated kinase,ROCK)作为RhoA下游的重要效应分子,通过调控微丝骨架组装和局部连接而在VSMC迁移和血管重构中发挥重要作用。醛固酮、一磷酸鞘氨醇、血小板源生长因子和血管紧张素Ⅱ等生物活性物质经相应受体激活Rho/ROCK信号通路调控VSMC迁移。研究Rho/ROCK在VSMC迁移中的作用对理解动脉粥样硬化、高血压等心血管疾病的病生理过程具有重要意义。
The migration of vascular smooth muscle cells（VSMCs） from media to intima is a critical step in the formation of atheroma and vascular stenosis as well as in the restenosis after vascular intervention.As an important downstream effector of RhoA,Rho-associated kinase（ROCK） plays an important role in VSMC migration and vascular remodeling by regulating actin filament cytoskeleton and focal adhesion.There are many bioactive substances such as aldosterone,sphingosine 1 phosphate（S1P）,platelet-derived growth factor（PDGF） and angiotensin II（Ang II） that could induce VSMC migration through Rho / ROCK pathway by binding to their specific receptors.Studies on Rho / ROCK pathway could help us to better understand how cardiovascular diseases such as atherosclerosis and hypertension develop.
出处
《生理科学进展》
CAS
CSCD
北大核心
2013年第4期269-274,共6页
Progress in Physiological Sciences
基金
国家自然基金(81000053)
国家基础科学人才培养基金(J1030831/J0108)资助课题
