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单核巨噬细胞系统对造血干细胞的调控作用

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摘要 单核巨噬细胞系统是机体重要的免疫防御屏障,包括骨髓中的单核细胞和组织中的巨噬细胞和树突状细胞,主要执行吞噬和抗原提呈功能。最近研究发现骨髓造血微环境中的单核/巨噬细胞不只是由造血干细胞(hematopoietic stem cells,HSCs)分化发育而成的一种执行防御功能的细胞群,还可以通过多种方式对HSCs的静止、自我更新、动员以及凋亡进行调控,但对其机制的研究还处于初步阶段。由于这些调控作用对于临床具有重要意义,因此本文对近年相关研究作一总结,进行综述。
作者 张宇辰 赵明峰
机构地区 天津医科大学一中心临床学院 天津市第一中心医院血液科
出处 《生理科学进展》 CAS CSCD 北大核心 2013年第4期310-313,共4页 Progress in Physiological Sciences
关键词 单核巨噬细胞系统 造血干细胞 干细胞龛 调控
分类号 R331 [医药卫生—人体生理学]
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参考文献15

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生理科学进展
2013年 第4期

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