摘要
目的探讨格列美脲联合甘精胰岛素治疗磺脲类药物继发性失效的2型糖尿病患者的疗效，安全性及胰岛B细胞功能变化。方法50例口服降糖药血糖控制不理想的2型糖尿病患者随机分为甘精胰岛素治疗组（甘精组，28例）和鱼精蛋白锌胰岛素治疗组（NPH组，22例），给予睡前皮下注射胰岛素联合口服格列美脲治疗12周，比较两组血糖，糖化血红蛋白（HbAlc）及血清C肽的变化。结果治疗后两组FBG、2hFBG、HbAlc均明显下降，甘精组低血糖事件明显少于NPH组（P〈0．01）。结论格列美脲联用甘精胰岛素治疗2型糖尿病的方案安全有效，能减少低血糖事件的发生。
Objective To investigate the curative effect,safety and the change of islet B ceil function of Glimepiride and insulin glargine united treatment in the secondary failure to sulfonylurea of type 2 diabetes mellitus patients. Methods 50 of type 2 diabetes mellitus patients whose blood glucose control is not satisfactory were randomly divided into two groups,these are patients treatment with insulin glargine group （glargine group,28cases） and patients treatment with protamine zinc insulin group （NPH group,22 cases）. Bedtime subcutaneous injection was given to the patients combined with oral Glimepiride therapy for 12 weeks,then compared the change of glucose,glycated hemoglobin（HbAlc） and serum C peptide in two groups. Results After treatment,FBG,2hFBG and HbAlc significantly decreased in both two groups,the hypoglycaemia patients in glargine group were significantly less than those in NPH group（P〈0.01）.Conclusions A combination treatment of Glimepiride and insulin glargine is safe and effective,which can reduce hypoglycaemia episodes.
