摘要
目的观察曲美他嗪、替米沙坦治疗糖尿病心脏病心力衰竭的临床疗效。方法82例糖尿病心脏病心力衰竭病例，随机分为两组，对照组常规抗心衰治疗，治疗组常规抗心衰治疗基础上加用盐酸曲美他嗪20mg，tid，替米沙坦40—80mg，1次／d，疗程4个月。疗效结束后观察B型尿钠肽（BNP）改善情况、心率和心功能疗效改善情况。结果治疗组较对照组BNP有明显降低，差异有显著性（P〈O．01）；两组治疗后心率无显著性。治疗组心功能改善总有效率为93．66％，优于对照组的总有效率76．42％，差异有显著性（P〈0．05）。结论盐酸曲美他嗪、替米沙坦联用可改善糖尿病心脏病心力衰竭患者的心功能，明显降低B型尿钠肽，疗效肯定，安全，值得临床推广.
Objective To observe the clinical efficacy of trimetazidine, telmisartan treatment of diabetic heart disease heart failure. Methods 82 cases of Diabetic Heart Failure patients were randomly divided into two groups, conventional therapy, the treatment group on the basis of conventional therapy plus trimetazidine 20 mg tid / d, telmisartan 40-80 rag, 1 times / d, 4 months treatment. Efficacy in comparison with B type natriuretic peptide （BNP） to improve the situation, heart rate and cardiac function in effect improve the situation. Results Treatment group than in the control group, BNP decreased significantly, there was a significant difference （P〈0.01）; the two groups after treatment had no significant change in heart rate. Improve heart function in treatment group the total effective rate was 93.66%, with an efficiency of 76.42% was better than the control group, there were significant differences （P〈0.05）.Conelusion Hydrochloric acid trimetazidine, telmisartan can improve cardiac function in patients with diabetic heart failure, decrease the B type natriuretic peptide, more effective, safe and worthy to be popularized.
