摘要
目的分析COPD合并肺部感染病例痰标本的病原学特征和对抗菌药物的耐药情况，为临床治疗该病提供科学合理的用药依据，避免滥用抗菌药物。方法对2010年1月-2012年12月在我院呼吸内科住院的147例COPD合并肺部感染患者的临床资料进行回顾性分析。结果147例肺部出现感染症状的COPD患者痰标本中，共分离出病原菌165株。其中，革兰氏阳性球菌56例，占22．08％；革兰氏阴性杆菌113例，占69．55％；真菌14例，占8．6％。革兰氏阳性病原菌主要为葡萄球菌，革兰氏阴性病原菌主要为鲍曼不动杆菌、大肠埃希氏菌、肺炎克雷伯菌和铜绿假单胞菌等，各种病原菌对不同抗菌药物的耐药特性也各不相同。结论提高痰标本病原菌的分离率，准确进行药敏试验，是临床治疗COPD合并肺部感染科学合理的用药依据。
Objective Analysis of the etiology of COPD pulmonary infection cases sputum specimens characteristics and bacterial resistance to antimicrobial agents,Provide a basis for scientific and rational medication in clinical treatment of the disease,To avoid abuse of antibacterial drugs.Method In January 2010 - December 2012 hospitalized in department of respiratory medicine of the clinical data of 147 patients with COPD pulmonary infection were retrospectively analyzed.Result 147 cases of pulmonary infection symptoms of sputum specimens in COPD patients,A total of 163 strains pathogenic bacteria isolated,Among them,Gram positive coccus 36 cases,Accounted for 22.08%;Gram negative bacillus in 113 cases,Accounted for 69.33%;Fungi 14 cases,Accounted for 8.6%.Gram- positive pathogenic bacteria mainly Staphylococcus,Gram-negative pathogens for Acinetobacter baumannii,E, coil bacteria,Klebsiella pneumoniae, Pseudomonas aeruginosa and so on,Various pathogenic bacteria drug resistance characteristics of different antimicrobial agents are different.Conclusion Increase the rate of sputum specimens pathogen separation,Accurate drug sensitive test,Clinical treatment of COPD pulmonary infection is scientific and rational drug use.
