乳腺肿瘤雌、孕激素受体表达与细胞增殖

The Relationship between Expression of Estrogen and Progesterone Receptors and Cell Proliferation in Breast Tumors

目的观察乳腺肿瘤雌、孕激素受体表达与细胞增殖的关系。方法用免疫细胞化学技术（ABC法）对经病理确诊的255例恶性和660例良性乳腺肿瘤进行了ER、PR、c－erbB－2、p53基因蛋白表达和Ki－67抗原检测。结果良、恶性乳腺肿瘤间，ER、PR阳性率均有极显著差异。良性肿瘤组中，ER＋PR＋组和ER－PR－组Ki－67表达有显著性差异。恶性肿瘤组中 Ki－67表达率在PR阴、阳性组及ER＋PR＋组和ER－PR－组间差异有显著性；p53表达率在ER、PR阴、阳性组间差异有显著性；c－erbB－2表达率在ER阴、阳性组及ER－PR－组和ER＋PR＋组间差异有显著性。结论良、恶性乳腺肿瘤ER、PR状况与Ki－67、p53、c－erbB－2过度表达密切相关但在良、恶性乳腺肿瘤中，ER、PR对细胞增殖的作用机制可能不同。恶性乳腺肿瘤中，c－erbB－2过度表达与ER关系密切。p53基因蛋白的过度表达与ER、PR状态均有关系，且其表达与ER、PR的变异无直接关系。

Objective To study the relationship between expression of estrogen receptor ER and progesterone receptor PR and cell proliferation． Methods The expression of ER PR c－erbB－2 p53 and Ki－67 were measured by immunoeytochemistry in 255 malignant and 660 benign breast tumors which all confirmed pathologically． Results It showed that there was significant difference of expressions of ER and PR between malignant and benign tumors． In benign group the expression of Ki－67 was significantly different between ER＋PR＋ and ER－PR－ groups． In malignant group the expression of Ki－67 in PR negative and ER－PR－ groups were higher than those in PR positive and ER＋PR＋ groups． The expression of p53 product was significantly different in ER and PR expressions． The expression of c－erbB－2 was significantly different between ER＋ and ER－ groups and there was significant difference between ER－PR－ and ER＋PR＋ groups． Conclusion The status of ER and PR closely related with Ki－67 p53 and c－erbB－2 in breast tumors but ER and PR might have some different mechanisms on cell proliferation between benign and malignant tumors． In malignant tumors there is significant difference between c－erbB－2 and ER or p53 and ERPR． No evidence shows that it relates with ER and PR variation．