宫颈癌卵巢移位术及术后卵巢功能的追踪观察

A follow-up study on the change of ovarian function in patients with cervical carcinoma receiving overian transposition

目的 :观察宫颈癌年轻患者卵巢移位术后卵巢内分泌的变化。方法 :对 1 0例年轻、早期宫颈癌患者在行根治术的同时行卵巢移位 ,其中 7例移位到髂脊上 2 cm皮下或腹外斜肌筋膜下方 ,3例移位到结肠旁沟中上侧腹部。 1 0例中 8例术后 1月行外照射放射治疗 ,总剂量 40～ 50 Gy。1 0例术前及术后 (包括放疗后 ) 6个月、1 a、2 a用放免法行血清性激素包括雌二醇 (E2 )、孕酮 (P)、睾酮 (T)、促卵泡素 (FSH)和促黄体素 (LH)检测。结果 :1 0例术前与术后 6个月、1 a、2 a的卵巢功能 ,差异无显著性 (P<0 .0 5)。结论 :卵巢移位术只要卵巢远离盆腔 ,放射量适当 ,术后可长期保留宫颈癌年轻患者的卵巢功能。

objective:To observe the change of ovarian function in patients with cervical cercinoma after ovarian transposition Methods:10 young patients with early carcinoma of the carvix were treated by ovarian tansposition before radical surgery,seven of them were displaced to 2 cm above the iliac crest subcutaneously Three were displaced to the abdomen at the paracolic groove 8 patients were received external pelvic radiotherapy in one month after operation,the total exposure dose(irradiation dosage)was 40～50 Gy The serum levels of sex hormones,including estradiol(E 2),progesterone(P),testosterone (T),follicle stimulating hormone (FSH) and luteotropic hormone (LH) were determined by radioimmunoassay before surgery and after radiotherapy Results:There are no significant difference in term of the change of sex hormones before and 6 month one year and two years after radiotherapy Conclusion:Ovarian transposition was helpful for reserving ovarian function in young patients with carcinoma of the cervix who have undergo radiotherapy