缺陷型与非缺陷型精神分裂症血液流变性对比研究

A COMPARISON STUDY ON THE HEMORHEOLOGICAL CHARACTERISTICS BETWEEN DEFICIT AND NONDEFICIT SCHIZOPHRENIA

目的：探讨缺陷型与非缺陷型精神分裂症的血液流变性特点。方法： 对140例精神分裂症患者按 Carpenter的标准划分为缺陷型和非缺陷型，并与 60名 健康人分别进行血液流变学指标检测，然后进行同性别比较。结果：患者不管男女， 其全血粘度、低切还原粘度和纤维蛋白原都显示缺陷型＞非缺陷型＞同性别健 康人，此外，缺陷型还有高血小板粘附率和低脑血流量，非缺陷型还显示高红细胞 聚集指数、高电泳率和低电泳时间。结论：精神分裂症的缺陷症状与高粘附低脑血 流量有关，定期检测血液流变学指标有助于指导治疗。

Objective: To explore the hemorheological charactristics in deficit and nondeficit schizophrenia. Methods: 140 cases of Schixophrenia were classified into deficit and nondeficit types by Carpenter's criterion. All the subjects amd 60 healthy were tested with the hemorheological indices and analyzed in accordance with the same sex. Results: In spite of male or female, the whole blood viscosity,low shear rate reduced viscosity and fibrinogen of the deficit schizophrenics showed signifiicantly higher than those of the nondeficit schizophrenics, and the latter showed significantly higher than those of the healthy. In addition, the deficit type showed higher platelet adherence late and lower cerebral blood flow and the nondeficit type showed higher aggregation index of red blood cell, higher electrophoresis rate and shorter electrophoresis the. Conclusion: The deficit symtoms of schizophrenia are related with high blood viscidity, high adherence and low cerebral blood flow. It is helpful for conducing treatment to test hemorheological indices periodically.