摘要
目的:探讨细胞色素 P450 2E1基因多态与肝癌的关系。方法:应用 PCR RFLP方法对 84例肝癌患者和 144例健康对照的细胞色素 P450 2E1基因 Rsa I多态进行检测。结果:病例组基因型 A频率为 71.43%,等位基因 c1频率为 84.52%,对照组则分别为 55.56%和 75.35%,两组差别均有统计学意义 (P0.05)。结论:细胞色素 P450 2E1基因 Rsa I多态位点的基因型 A或等位基因 c1增加了个体患肝癌的危险性。
Objective: To investigate the relationship between genetic polymorphism of cytochrome P450 2E1(CYP2E1) and susceptibility to hepatocellular carcinoma (HCC). Methods: The Rsa I polymorphism of CYP2E1 of 84 patients with HCC and 144 healthy controls were detected by PCR RFLP. Results: The frequencies of genotype A and allele c1 in the patients were 71.43% and 84.52% respectively, and in the controls were 55.56% and 75.35% respectively. The differences were statistically significant(P
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第10期862-864,共3页
Chinese Journal of Cancer
基金
本课题受卫生部科研基金 !(NO: 96- 1- 189)