细胞色素P450 2E1基因多态与肝癌遗传易感性研究

Genetic polymorphism of cytochrome P450 2E1and susceptibility to hepatocellular carcinoma

目的：探讨细胞色素 P450 2E1基因多态与肝癌的关系。方法：应用 PCR RFLP方法对 84例肝癌患者和 144例健康对照的细胞色素 P450 2E1基因 Rsa I多态进行检测。结果：病例组基因型 A频率为 71.43％，等位基因 c1频率为 84.52％，对照组则分别为 55.56％和 75.35％，两组差别均有统计学意义 (P0.05)。结论：细胞色素 P450 2E1基因 Rsa I多态位点的基因型 A或等位基因 c1增加了个体患肝癌的危险性。

Objective: To investigate the relationship between genetic polymorphism of cytochrome P450 2E1(CYP2E1) and susceptibility to hepatocellular carcinoma (HCC). Methods: The Rsa I polymorphism of CYP2E1 of 84 patients with HCC and 144 healthy controls were detected by PCR RFLP. Results: The frequencies of genotype A and allele c1 in the patients were 71.43％ and 84.52％ respectively, and in the controls were 55.56％ and 75.35％ respectively. The differences were statistically significant(P