声门上喉鳞癌nm23H1、表皮生长因子受体表达及其与颈淋巴结转移和预后的关系

Expression of nm23H1,epidermal growth factor receptor in supraglottic carcinoma and their relationship with cervical lymph node metastasis and prognosis

目的 :研究声门上喉癌中 nm23H1,表皮生长因子受体 (epidermal growth factor receptor,EGFR)表达及其与颈淋巴结转移和预后的关系。方法：回顾分析 77例声门上喉鳞癌和 23例癌旁正常喉粘膜标本。应用免疫组化技术研究 nm23H1,EGFR的表达。结果：声门上喉鳞癌中 nm23H1,EGFR的阳性表达率为 76.62％和 72.73％。声门上喉鳞癌和癌旁正常喉粘膜中 nm23H1和 EGFR表达具有显著差异（

Objective: To investigate nm23H1, epidermal growth factor receptor (EGFR) expression in supraglottic carcinoma and their relationship with cervical lymph node metastasis and prognosis. Methods: A total of 77 cases of supraglottic squamous cell carcinomas (SGSCC) and 23 normal laryngeal mucosa near tumor were reviewed. Immunohistochemical technique was used to determine the expression of nm23H1 and EGFR. Their relationship with lymph node metastasis and prognosis of the patient was investigated retrospectively. Results: The positive rate of nm23H1 and EGFR in SGSCC was 76.62％ and 72.73％ respectively. There was significant difference between SGSCC and normal laryngeal mucosa near tumor (P