肥大细胞在子宫内膜异位症疼痛发生机制中的研究进展

Research advances on the role of mast cells in pelvic pain of endometriosis

子宫内膜异位症(内异症)是严重影响妇女身心健康的一种常见妇科疾病,但其发病机制及其发生疼痛的相关机制至今不清。肥大细胞(MC)是一种多功能的免疫细胞,最近国内外研究发现,内异症病灶中存在的神经纤维可释放神经肽类物质(如神经生长因子和P物质等),其能促使病灶中的MC脱颗粒,释放组胺、蛋白酶、细胞因子、趋化因子等致痛介质,造成内异症疼痛症状。

Endometriosis （EMs） is a common gynecologic disease that affects women＇s physical and mental health seriously. The pathogenesis is still unknown and the mechanism of endometriosis-associated pain remains unclear. Mast cells （MC） are known to be multifunctional players in the immune system. Recent studies have shown that nerve fibers in EMs lesions can release neural peptides such as nerve growth factor and substance P to induce MC degranulating and releasing histamine, proteases, cytokines, chemokines etc. , which contributes to the development of pain and hyperalgesia in patients with endometriosis.