狼疮性肾炎的预后影响因素

Predictive Factors for the Prognosis of Lupus Nephritis

目的 探讨狼疮性肾炎早期临床表现、生化与病理指标与患者 5年肾功能稳定率的关系 ,为指导临床预后判断和治疗提供依据。方法 采用COX比例风险模型 ,对 5 5例狼疮性肾炎的临床、生化、病理资料进行预后分析。结果 病程初期的 2 4h尿蛋白定量越高 ,间质炎症、小管萎缩、间质纤维化病变越严重 ,慢性病变越严重 ,则肾功能恶化危险性越大。结论 2 4h尿蛋白定量、间质炎症、间质纤维化程度及小管萎缩 ,是能够提示狼疮性肾炎

Purpose To analyze the relationship between the early clinical manifestations,biochemical parameters,pathological indexes and the 5 year renal function stability rate in lupus nephritis(LN),and to provide the markers for clinical prognosis and treatment in LN. Methods COX proportional hazards model was used in the survival analysis of the clinicopathological features in 55 patients with LN. Results The results revealed that the higher urine protein excretion and the more serious changes in renal interstitial inflammation,fibrosis,and tubular atrophy,the more incidences to develop the renal function deterioration. Conclusions The 24 h urinary protein excretion,score of tubulointerstitial lesions,including interstitial inflammation,fibrosis and tubular atrophy were found as useflu predictive markers for 5 year renal function stability rate in LN.