氯丙嗪对精神分裂症的疗效与5-HT2a受体基因的关系

Relationship between the Responses to Chlorpromazine for Schizophrenia and the 5-HT2a Receptor Gene

目的 探讨与氯丙嗪对精神分裂症疗效有关的 5 HT2a受体基因的基因型以及其他相关的因素。方法 抽取 10 5例连续住院的精神分裂症患者 ,给予氯丙嗪≥ 30 0mg/d治疗 2个月 ,用PANSS量表评定氯丙嗪疗效 ,用多聚酶链式反应扩增及限制性片段长度多态性 (PCR RFLPs)技术测定所研究对象的基因型和等位基因。所得资料以 χ2 、t检验及Logistic回归分析。结果 发现氯丙嗪对精神分裂症患者的疗效与患者总病程明显负相关 ,而与 5 HT2a受体基因以及其他因素无关。结论 氯丙嗪对病程越短的精神分裂症患者疗效越好 ;5

Purpose To investigate the relationship between the responses to chlorpromazine for schizophrenic patients and the 5?HT2a receptor gene and other related factors. Methods One hundred and five in patients with schizophrenia were treated with chlorpromazine (≥300 mg/d) for 2 months.The responses to chlorpromazine were rated with positive and negative symptom scale(PANSS) and the genotypes and alleles in these patients were examined with PCR amplification and restriction fragment length polymorphisms(RFLPs) technique.All the data were analyzed by χ 2 and t tests and logistic regression analysis. Results The responses to chlorpromazine for schizophrenic patients are significantly negatively related to the course,but not related to the 5?HT2a receptor gene and the other factors. Conclusions The responses to chlorpromazine for the schizophrenic patients with shorter course are better than those with longer course.The 5?HT2a receptor gene does not play a major role in the pharmacological action of chlorpromazine.