人胎盘型谷胱甘肽S-转移酶在肝细胞癌中的表达

Expression of GST-π in Human Hepatocellular Carcinoma

应用免疫组织化学SP法 ,对正常肝组织、慢性肝炎、肝硬化、癌旁肝硬化和肝细胞癌共 12 1例进行人胎盘型谷胱甘肽S -转移酶 (GST -π)和甲胎蛋白 (AFP)的检测 .结果 :正常肝组织GST -π和AFP均不表达 ;慢性肝炎GST -π阳性率为 2 5% ( 5/ 2 0 ) ,AFP为阴性 ;肝硬化GST -π阳性率为 19% ( 5/2 7) ,AFP为阴性 ;癌旁肝硬化GTP -π阳性率为 52 % ( 14/ 2 7) ,AFP阳性率为 3 3 % ( 9/ 2 7) ;肝细胞癌GST-π阳性率为 61% ( 2 3 / 3 8) ,AFP阳性率为 4 5% ( 17/ 3 8) .提示 :癌旁肝硬化不同于不伴肝癌的肝硬化而更具癌前病变性质 ;GST

The expression of GST-π and AFP were investigated by immunohistochemical SP method in 121 cases of normal liver, chronic hepatitis, liver cirrhosis, pericancerous cirrhosis and hepatocellular carcinoma (HCC). The results showed that expression of GST-π and AFP were negative in normal liver. The expression rate of GST-π was 25% (5/20) and AFP was negative (0/20) in chronic hepatitis. The expression rate of GST-π was 19%(5/27) and AFP was negative in liver cirrhosis. The expression rate of GST-πwas 52%(14/27) and AFP was 33%(9/27) in pericancerous cirrhosis. The expression rate of GST-π 61%(23/38) and AFP was 45%(17/38). These results suggest: 1) The pericancerous cirrhosis differed essentially from the liver cirrhosis without tumor, and was more closely linked with HCC; 2) Immunohistochemical detection of GST-πand AFP could diagnose and forecast HCC in advance.