奥美拉唑钠对实验性溃疡的抑制作用

The Inhibitory Effect of Sodium Omeprazole on Experimental Gastric Ulcer

研究表明 ,国产奥美拉唑钠在 5.6～ 3 5mg· kg-1剂量下 ,对小鼠水浸应激性溃疡的形成有显著的抑制作用 ,溃疡形成的抑制率为 54%～ 82 % ;在 3 .5～ 7mg· kg-1剂量下 ,对幽门结扎型大鼠胃溃疡模型的形成具有显著的抑制作用 ,溃疡形成的抑制率为 89%～ 99%。由此表明 ,国产奥美拉唑钠与进口奥美拉唑钠的抗溃疡作用强度基本一致。

The local made sodium omeprazole under the dose of 5.6～35mg·kg\+\{-1\} was shown to significantly inhibit ulcerogenesis in the water droping induced model in mice,the inhibitory efficiency was 54%～82%;Under the dose of 3.5～7mg·kg \+\{-1\},it was found to significantly inhibit ulcerogenesis in pyloric ligation model in rats,the inhibitory efficieney was 88%～99%.Thus,the potency of antiulcer effect of the local made sodium omeprazole is about the same as that of the imported.